| State: | NC |
| Type: | NC |
| Route: | 343 |
| Map: | NC 343 map.svg |
| Length Mi: | 25.5 |
| Length Round: | 1 |
| Established: | 1930 |
| Direction A: | South |
| Terminus A: | Wharf Road in Old Trap |
| Junction: | in Camden |
| Direction B: | North |
| Terminus B: | in South Mills |
| Previous Type: | US |
| Previous Route: | 321 |
| Next Type: | NC |
| Next Route: | 344 |
North Carolina Highway 343 (NC 343) is a primary state highway in the U.S. state of North Carolina. It serves to connect the county seat of Camden with both the north and south ends of Camden County.
NC 343 begins at the intersection of Wharf Road (SR 1104) and Texas Road (SR 1100) in Old Trap. Going in an northwesterly direction and parallel to Pasquotank River to its west, it goes through the communities of Alder Branch, Shiloh and Taylors Beach. Passing through Camden, it links with U.S. Route 158 (US 158). Continuing northwesterly, it continues through the communities of Spences Corner, Lambs Corner, Burnt Mills and finally South Mills, where it joins US 17 Business (US 17 Bus.). Routed alongside the Dismal Swamp Canal, it ends at US 17 just north of South Mills.
The northern section, between Camden and South Mills, is frequently used in the summer months as an alternative route to and from the Outer Banks, from travelers from the Hampton Roads metro area of Virginia.