Nizofenone Explained

Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.^{[1] [2] [3] [4]}

Further reading

• Yasuda H . Prevention of neurodegeneration by a neuroprotective radical scavenger . Annals of the New York Academy of Sciences . 893 . 1. 430–433 . 1999 . 10672283 . 10.1111/j.1749-6632.1999.tb07871.x . 1999NYASA.893..430Y . 21398803 .
• Hayashi Y, Shimada O, Yasuda H, Ikegami K . Effect of nizofenone on experimental head trauma in mice . Archives Internationales de Pharmacodynamie et de Therapie . 328 . 3 . 251–260 . 1994 . 7625881 .
• Yasuda H, Kishiro K, Izumi N, Nakanishi M . Biphasic liberation of arachidonic and stearic acids during cerebral ischemia . Journal of Neurochemistry . 45 . 1 . 168–172 . July 1985 . 2987409 . 10.1111/j.1471-4159.1985.tb05489.x . 24857145 .
• Yasuda H, Ochi H, Tsumagari T . Stimulation of prostacyclin synthesis by nizofenone . Biochemical Pharmacology . 33 . 17 . 2707–2709 . September 1984 . 6431991 . 10.1016/0006-2952(84)90684-1 .
• Saito I, Asano T, Ochiai C, Takakura K, Tamura A, Sano K . A double-blind clinical evaluation of the effect of Nizofenone (Y-9179) on delayed ischemic neurological deficits following aneurysmal rupture . Neurological Research . 5 . 4 . 29–47 . 1983 . 6149485 . 10.1080/01616412.1983.11739654 .
• Ochiai C, Asano T, Takakura K, Fukuda T, Horizoe H, Morimoto Y . Mechanisms of cerebral protection by pentobarbital and nizofenone correlated with the course of local cerebral blood flow changes . Stroke . 13 . 6 . 788–796 . 1982 . 7147293 . 10.1161/01.str.13.6.788 . free .
• Yasuda H, Shimada O, Nakajima A, Asano T . Cerebral protective effect and radical scavenging action . Journal of Neurochemistry . 37 . 4 . 934–938 . October 1981 . 7320731 . 10.1111/j.1471-4159.1981.tb04480.x . 22484255 .
• Yasuda H, Nakanishi M, Tsumagari T, Nakajima A, Nakanishi M . The mechanism of action of a novel cerebral protective drug against anoxia I. The effect on cerebral energy demand . Archives Internationales de Pharmacodynamie et de Therapie . 242 . 1 . 77–85 . November 1979 . 543750 .
• Tamura A, Asano T, Sano K, Tsumagari T, Nakajima A . Protection from cerebral ischemia by a new imidazole derivative (Y-9179) and pentobarbital. A comparative study in chronic middle cerebral artery occlusion in cats . Stroke . 10 . 2 . 126–134 . 1979 . 442136 . 10.1161/01.str.10.2.126 . free .

Notes and References

1. Ohta T, Kikuchi H, Hashi K, Kudo Y . Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study . Journal of Neurosurgery . 64 . 3 . 420–426 . March 1986 . 3512795 . 10.3171/jns.1986.64.3.0420 .
2. Book: Yasuda H, Izumi N, Nakanishi M, Maruyama Y . Oxygen Transport to Tissue X . Brain Protection Against Oxygen Deficiency by Nizofenone . Advances in Experimental Medicine and Biology . 222 . 403–10 . 3364265 . 10.1007/978-1-4615-9510-6_48 . 1988 . 978-1-4615-9512-0 .
3. Yasuda H, Nakajima A . Brain protection against ischemic injury by nizofenone . Cerebrovascular and Brain Metabolism Reviews . 5 . 4 . 264–276 . 1993 . 8110594 .
4. Matsumoto Y, Aihara K, Kamata T, Goto N . Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation . European Journal of Pharmacology . 262 . 1–2 . 157–161 . September 1994 . 7813567 . 10.1016/0014-2999(94)90039-6 .