Nedaplatin Explained

Nedaplatin (INN, marketed under the tradename Aqupla) is a platinum-based antineoplastic drug which is used for cancer chemotherapy.^[1] The complex consists of two ammine ligands and the dianion derived from glycolic acid.

Platinum-based drugs are widely employed as antineoplastic agents, especially cisplatin and carboplatin. Due to issues of their toxicity and number of cisplatin-resistant cancer cells, other platinum derivatives have been developed. Nedaplatin is one example of such new drugs.^[2]

External links

• Web site: Aqupla アクプラ . Shionogi & Co. . March 2007 . https://web.archive.org/web/20040805180548/http://www.shionogi.co.jp/med/kihon/img/pdf/AQP.pdf . 2004-08-05 .
• Web site: Official Shionogi & Co. Website . Japanese .

Notes and References

1. Apps MG, Choi EH, Wheate NJ . The state-of-play and future of platinum drugs . Endocrine-Related Cancer . 22 . 4 . R219-33 . August 2015 . 26113607 . 10.1530/ERC-15-0237 . free . Nial J. Wheate . 2123/24426 . free .
2. Johnstone TC, Park GY, Lippard SJ . Understanding and improving platinum anticancer drugs--phenanthriplatin . Anticancer Research . 34 . 1 . 471–6 . January 2014 . 24403503 . 3937549 . Stephen J. Lippard .