| Country: | MMR |
| Type: | NH |
| Route: | 2 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | Yangon |
| Terminus B: | Mandalay |
| Cities: | Pyay, Magwe, Kyaukpadaung, Myingyan |
National Highway 2 (NR2) is a south–north flowing highway of central-western Burma.
The highway begins at Satthwadaw, to the north of Yangon at 17.0417°N 96.1322°W where it is fed by the National Highway 1 and then branches off to the northwest. At Myingyan it joins the National Road 18. At this point the road forks to the east and eventually rejoins National Highway 1 near the village of Gyobinchan in Myittha Township at 21.3831°N 96.1756°W. The highway mostly follows the course of the Ayeyarwady River on its eastern bank.