NPTN explained

Neuroplastin is a protein that in humans is encoded by the NPTN gene.^{[1] [2] [3]}

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"^{[4] [5] [6]}

Further reading

• Langnaese K, Beesley PW, Gundelfinger ED . Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily. . J. Biol. Chem. . 272 . 2 . 821–7 . 1997 . 8995369 . 10.1074/jbc.272.2.821 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Saito A, Fujikura-Ouchi Y, Kuramasu A, etal . Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia. . Neurosci. Lett. . 411 . 3 . 168–73 . 2007 . 17123723 . 10.1016/j.neulet.2006.08.042 . 36492996 .
• Bernstein HG, Smalla KH, Bogerts B, etal . The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain. . Brain Res. . 1134 . 1 . 107–12 . 2007 . 17196182 . 10.1016/j.brainres.2006.11.090 . 31095277 .

Notes and References

1. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal Biochem . 236 . 1 . 107–13 . Jun 1996 . 8619474 . 10.1006/abio.1996.0138 .
2. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res . 7 . 4 . 353–8 . Jun 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353.
3. Web site: Entrez Gene: NPTN neuroplastin.
4. https://web.archive.org/web/20140211184043/http://www.telegraph.co.uk/science/science-news/10631319/Is-intelligence-written-in-the-genes.html Is intelligence written in the genes?
5. http://www.natureworldnews.com/articles/5974/20140211/researchers-find-gene-links-grey-matter-intelligence.htm Researchers Find Gene that Links Grey Matter with Intelligence
6. http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2013197a.html Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents