NOX3 explained

NADPH oxidase 3 is an enzyme that in humans is encoded by the NOX3 gene.^{[1] [2]}

Function

NADPH oxidases, such as NOX3, are plasma membrane-associated enzymes found in many cell types. They catalyze the production of superoxide by a 1-electron reduction of oxygen, using NADPH as the electron donor.[supplied by OMIM]^[3]

Further reading

• Lachgar A, Sojic N, Arbault S, Bruce D, Sarasin A, Amatore C, Bizzini B, Zagury D, Vuillaume M . Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins . J. Virol. . 73 . 2 . 1447–52 . 1999 . 9882350 . 103969 . 10.1128/JVI.73.2.1447-1452.1999.
• Kikuchi H, Hikage M, Miyashita H, Fukumoto M . NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells . Gene . 254 . 1–2 . 237–43 . 2000 . 10974555 . 10.1016/S0378-1119(00)00258-4 .
• Cheng G, Ritsick D, Lambeth JD . Nox3 regulation by NOXO1, p47phox, and p67phox . J. Biol. Chem. . 279 . 33 . 34250–5 . 2004 . 15181005 . 10.1074/jbc.M400660200 . free .
• Jana A, Pahan K . Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase . J. Neurosci. . 24 . 43 . 9531–40 . 2004 . 15509740 . 1955476 . 10.1523/JNEUROSCI.3085-04.2004 .
• Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H . The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators . J. Biol. Chem. . 280 . 24 . 23328–39 . 2005 . 15824103 . 10.1074/jbc.M414548200 . free .
• Ueyama T, Geiszt M, Leto TL . Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases . Mol. Cell. Biol. . 26 . 6 . 2160–74 . 2006 . 16507994 . 1430270 . 10.1128/MCB.26.6.2160-2174.2006 . 2018-11-04 . 2020-10-09 . https://web.archive.org/web/20201009210504/http://www.lib.kobe-u.ac.jp/repository/90000354.pdf . dead .
• Carnesecchi S, Carpentier JL, Foti M, Szanto I . Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3 . Exp. Cell Res. . 312 . 17 . 3413–24 . 2006 . 16949073 . 10.1016/j.yexcr.2006.07.003 .
• Nakano Y, Banfi B, Jesaitis AJ, Dinauer MC, Allen LA, Nauseef WM . Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3 . Biochem. J. . 403 . 1 . 97–108 . 2007 . 17140397 . 1828898 . 10.1042/BJ20060819 .
• Chen G, Adeyemo AA, Zhou J, Chen Y, Doumatey A, Lashley K, Huang H, Amoah A, Agyenim-Boateng K, Eghan BA, Okafor G, Acheampong J, Oli J, Fasanmade O, Johnson T, Rotimi C . A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes . Am. J. Kidney Dis. . 49 . 3 . 394–400 . 2007 . 17336700 . 10.1053/j.ajkd.2006.12.011 .

Notes and References

1. Herb M . NADPH oxidase 3: Beyond the innear ear . Antioxidants . 13 . 2 . February 2024 . 219 . 10.3390/antiox13020219 . free . 38397817 . 10886416 .
2. Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD . Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5 . Gene . 269 . 1–2 . 131–40 . May 2001 . 11376945 . 10.1016/S0378-1119(01)00449-8 .
3. Web site: Entrez Gene: NOX3 NADPH oxidase 3.