NOLA2 explained

H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene.^{[1] [2]}

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.

The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Henras A, Henry Y, Bousquet-Antonelli C, etal . Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. . EMBO J. . 17 . 23 . 7078–90 . 1999 . 9843512 . 10.1093/emboj/17.23.7078 . 1171055 .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Kang HS, Jung HM, Jun DY, etal . Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells. . Biochim. Biophys. Acta . 1575 . 1–3 . 31–9 . 2002 . 12020816 . 10.1016/s0167-4781(02)00240-3.
• Scherl A, Couté Y, Déon C, etal . Functional proteomic analysis of human nucleolus. . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Wang C, Meier UT . Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. . EMBO J. . 23 . 8 . 1857–67 . 2005 . 15044956 . 10.1038/sj.emboj.7600181 . 394235 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Slizhikova DK, Vinogradova TV, Sverdlov ED . [The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer] . Bioorg. Khim. . 31 . 2 . 195–9 . 2005 . 15889794 . 10.1007/s11171-005-0024-6. 21342977 .

Notes and References

1. Pogacic V, Dragon F, Filipowicz W . Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10 . Mol Cell Biol . 20 . 23 . 9028–40 . Dec 2000 . 11074001 . 86556 . 10.1128/MCB.20.23.9028-9040.2000 .
2. Web site: Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs).