NLGN1 explained

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.^{[1] [2] [3]}

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.^[4]

Interactions

NLGN1 has been shown to interact with NRXN1^{[5] [6]} and DLG4.^[7]

See also

• Neurexins: NRXN1, NRXN2, NRXN3

Further reading

• Cantallops I, Cline HT . Synapse formation: if it looks like a duck and quacks like a duck .. . Current Biology . 10 . 17 . R620–3 . September 2000 . 10996085 . 10.1016/S0960-9822(00)00663-1. 15851386 . free .
• Ichtchenko K, Hata Y, Nguyen T, etal . Neuroligin 1: a splice site-specific ligand for beta-neurexins . Cell . 81 . 3 . 435–43 . May 1995 . 7736595 . 10.1016/0092-8674(95)90396-8. 15638953 . free .
• Ichtchenko K, Nguyen T, Südhof TC . Structures, alternative splicing, and neurexin binding of multiple neuroligins . The Journal of Biological Chemistry . 271 . 5 . 2676–82 . February 1996 . 8576240 . 10.1074/jbc.271.5.2676. free .
• Irie M, Hata Y, Takeuchi M, etal . Binding of neuroligins to PSD-95 . Science . 277 . 5331 . 1511–5 . September 1997 . 9278515 . 10.1126/science.277.5331.1511.
• Kikuno R, Nagase T, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 6 . 3 . 197–205 . June 1999 . 10470851 . 10.1093/dnares/6.3.197. free .
• Scheiffele P, Fan J, Choih J, Fetter R, Serafini T . Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons . Cell . 101 . 6 . 657–69 . June 2000 . 10892652 . 10.1016/S0092-8674(00)80877-6. 16095623 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proceedings of the National Academy of Sciences of the United States of America . 99 . 26 . 16899–903 . December 2002 . 12477932 . 139241 . 10.1073/pnas.242603899. 2002PNAS...9916899M . free .
• Comoletti D, Flynn R, Jennings LL, etal . Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta . The Journal of Biological Chemistry . 278 . 50 . 50497–505 . December 2003 . 14522992 . 10.1074/jbc.M306803200. free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nature Genetics . 36 . 1 . 40–5 . January 2004 . 14702039 . 10.1038/ng1285. free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Research . 14 . 10B . 2121–7 . October 2004 . 15489334 . 528928 . 10.1101/gr.2596504.
• Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC . Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism . The Journal of Biological Chemistry . 280 . 23 . 22365–74 . June 2005 . 15797875 . 10.1074/jbc.M410723200. free .
• Muzny DM, Scherer SE, Kaul R, etal . The DNA sequence, annotation and analysis of human chromosome 3 . Nature . 440 . 7088 . 1194–8 . April 2006 . 16641997 . 10.1038/nature04728. 2006Natur.440.1194M . free .
• Li X, Zhang J, Cao Z, Wu J, Shi Y . Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin . Protein Science . 15 . 9 . 2149–58 . September 2006 . 16882988 . 2242614 . 10.1110/ps.062087506.

Notes and References

1. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI . The structure and expression of the human neuroligin-3 gene . Gene . 246 . 1–2 . 303–10 . April 2000 . 10767552 . 10.1016/S0378-1119(00)00049-4.
2. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 7 . 2 . 143–50 . April 2000 . 10819331 . 10.1093/dnares/7.2.143. free .
3. Web site: Entrez Gene: NLGN1 neuroligin 1.
4. Scheiffele P, Fan J, Choih J, Fetter R, Serafini T . Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons . Cell . 101 . 6 . 657–69 . June 2000 . 10892652 . 10.1016/S0092-8674(00)80877-6. 16095623 . free .
5. Comoletti D, Flynn R, Jennings LL, etal . Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta . The Journal of Biological Chemistry . 278 . 50 . 50497–505 . December 2003 . 14522992 . 10.1074/jbc.M306803200. free .
6. Ichtchenko K, Nguyen T, Südhof TC . Structures, alternative splicing, and neurexin binding of multiple neuroligins . The Journal of Biological Chemistry . 271 . 5 . 2676–82 . February 1996 . 8576240 . 10.1074/jbc.271.5.2676. free .
7. Irie M, Hata Y, Takeuchi M, etal . Binding of neuroligins to PSD-95 . Science . 277 . 5331 . 1511–5 . September 1997 . 9278515 . 10.1126/science.277.5331.1511.