NFATC3 explained

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.^{[1] [2]}

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.^[2]

See also

• NFAT

Further reading

• Rao A, Luo C, Hogan PG . Transcription factors of the NFAT family: regulation and function . Annual Review of Immunology . 15 . 707–47 . 1997 . 9143705 . 10.1146/annurev.immunol.15.1.707 .
• Crabtree GR . Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT . Cell . 96 . 5 . 611–4 . Mar 1999 . 10089876 . 10.1016/S0092-8674(00)80571-1 . 8817053 . free .
• Horsley V, Pavlath GK . NFAT: ubiquitous regulator of cell differentiation and adaptation . The Journal of Cell Biology . 156 . 5 . 771–4 . Mar 2002 . 11877454 . 2173310 . 10.1083/jcb.200111073 .
• Masuda ES, Naito Y, Tokumitsu H, Campbell D, Saito F, Hannum C, Arai K, Arai N . NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus . Molecular and Cellular Biology . 15 . 5 . 2697–706 . May 1995 . 7739550 . 230500 . 10.1128/mcb.15.5.2697.
• Jabado N, Le Deist F, Fisher A, Hivroz C . Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity . European Journal of Immunology . 24 . 11 . 2646–52 . Nov 1994 . 7957556 . 10.1002/eji.1830241112 . 30435577 .
• Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A . Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif . Biochemical and Biophysical Research Communications . 205 . 1 . 467–74 . Nov 1994 . 7999066 . 10.1006/bbrc.1994.2689 .
• Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT . Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering . European Journal of Immunology . 26 . 9 . 2181–8 . Sep 1996 . 8814265 . 10.1002/eji.1830260933 . 23430217 .
• Masuda ES, Liu J, Imamura R, Imai SI, Arai KI, Arai N . Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain . Molecular and Cellular Biology . 17 . 4 . 2066–75 . Apr 1997 . 9121455 . 232054 . 10.1128/mcb.17.4.2066.
• Chow CW, Rincón M, Cavanagh J, Dickens M, Davis RJ . Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway . Science . 278 . 5343 . 1638–41 . Nov 1997 . 9374467 . 10.1126/science.278.5343.1638 . 1997Sci...278.1638C .
• Amasaki Y, Masuda ES, Imamura R, Arai K, Arai N . Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets . Journal of Immunology . 160 . 5 . 2324–33 . Mar 1998 . 10.4049/jimmunol.160.5.2324 . 9498773 . 19932048 . free .
• Zhu J, Shibasaki F, Price R, Guillemot JC, Yano T, Dötsch V, Wagner G, Ferrara P, McKeon F . Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1 . Cell . 93 . 5 . 851–61 . May 1998 . 9630228 . 10.1016/S0092-8674(00)81445-2 . 9515426 . free .
• Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG . Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT . Molecular Cell . 1 . 5 . 627–37 . Apr 1998 . 9660947 . 10.1016/S1097-2765(00)80063-5 . free .
• Imamura R, Masuda ES, Naito Y, Imai S, Fujino T, Takano T, Arai K, Arai N . Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells . Journal of Immunology . 161 . 7 . 3455–63 . Oct 1998 . 10.4049/jimmunol.161.7.3455 . 9759864 . 24271152 . free .
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q . Genomics . 60 . 3 . 295–308 . Sep 1999 . 10493829 . 10.1006/geno.1999.5927 .
• Amasaki Y, Adachi S, Ishida Y, Iwata M, Arai N, Arai K, Miyatake S . A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells . The Journal of Biological Chemistry . 277 . 28 . 25640–8 . Jul 2002 . 11997392 . 10.1074/jbc.M201860200 . 27918489 . free .
• Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A . A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis . American Journal of Human Genetics . 71 . 6 . 1443–9 . Dec 2002 . 12417987 . 378590 . 10.1086/344580 .

Notes and References

1. Hoey T, Sun YL, Williamson K, Xu X . Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins . Immunity . 2 . 5 . 461–72 . May 1995 . 7749981 . 10.1016/1074-7613(95)90027-6 . free .
2. Web site: Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3.