NEMF (gene) explained

Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.^[1]

Function

This gene encodes a component of the ribosome quality control complex.^[2] The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.

Notes and References

1. Web site: Entrez Gene: Nuclear export mediator factor .
2. Shao S, Brown A, Santhanam B, Hegde RS . Structure and assembly pathway of the ribosome quality control complex . Molecular Cell . 57 . 3 . 433–44 . February 2015 . 25578875 . 10.1016/j.molcel.2014.12.015 . 4321881 .