NEGR1 explained

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.^[1]

Clinical significance

Variants of the NEGR1 gene may be associated with obesity and major depression.^{[2] [3] [4]}

Further reading

• Elortza F, Mohammed S, Bunkenborg J, etal . Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment . J. Proteome Res. . 5 . 4 . 935–43 . 2006 . 16602701 . 10.1021/pr050419u .
• Haupt A, Thamer C, Heni M, etal . Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study . Obesity (Silver Spring) . 18. 6. 1212–7 . 2009 . 19910938 . 10.1038/oby.2009.413 . free .
• Li S, Zhao JH, Luan J, etal . Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies . Am. J. Clin. Nutr. . 91 . 1 . 184–90 . 2010 . 19812171 . 10.3945/ajcn.2009.28403 . free .
• Brandys MK, van Elburg AA, Loos RJ, etal . Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 153B . 2 . 695–9 . 2010 . 19746409 . 10.1002/ajmg.b.31026 . 45793585 .
• Renström F, Payne F, Nordström A, etal . Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden . Hum. Mol. Genet. . 18 . 8 . 1489–96 . 2009 . 19164386 . 10.1093/hmg/ddp041 . 2664142 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Bauer F, Elbers CC, Adan RA, etal . Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference . Am. J. Clin. Nutr. . 90 . 4 . 951–9 . 2009 . 19692490 . 10.3945/ajcn.2009.27781 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Hom G, Graham RR, Modrek B, etal . Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX . N. Engl. J. Med. . 358 . 9 . 900–9 . 2008 . 18204098 . 10.1056/NEJMoa0707865 . free .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Yang Q, Kathiresan S, Lin JP, etal . Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study . BMC Med. Genet. . 8. S12 . 2007 . Suppl 1 . 17903294 . 10.1186/1471-2350-8-S1-S12 . 1995619 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hotta K, Nakamura M, Nakamura T, etal . Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population . J. Hum. Genet. . 54 . 12 . 727–31 . 2009 . 19851340 . 10.1038/jhg.2009.106 . free .
• Thorleifsson G, Walters GB, Gudbjartsson DF, etal . Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity . Nat. Genet. . 41 . 1 . 18–24 . 2009 . 19079260 . 10.1038/ng.274 . 764409 .

Notes and References

1. Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S . Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family . J. Biol. Chem. . 274 . 12 . 8224–30 . March 1999 . 10075727 . 10.1074/jbc.274.12.8224. free .
2. Thorleifsson G, Walters GB, Gudbjartsson DF, etal . Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. . Nat. Genet. . 41 . 1 . 18–24 . January 2009 . 19079260 . 10.1038/ng.274. 764409 .
3. Willer CJ, Speliotes EK, Loos RJ, etal . Six new loci associated with body mass index highlight a neuronal influence on body weight regulation . Nat. Genet. . 41 . 1 . 24–34 . January 2009 . 19079261 . 10.1038/ng.287. 2695662 .
4. Zhao J, Bradfield JP, Li M, etal . The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI . Obesity (Silver Spring) . 17. 12. 2254–7. May 2009 . 19478790 . 10.1038/oby.2009.159 . 2860782.