| Murrieta Mesa High School | |
| Motto: | Pursue Your Passion, Leave A Legacy[1] |
| Address: | 24801 Monroe Avenue |
| City: | Murrieta |
| State: | California |
| Zipcode: | 92562 |
| Country: | United States |
| Type: | Public high school |
| Established: | [2] |
| District: | Murrieta Valley Unified School District |
| Principal: | Scott Richards Jr.[3] |
| Teaching Staff: | 95.29 (FTE) |
| Grades: | 9–12 |
| Enrollment: | 2,178 (2022–2023) |
| Ratio: | 22.86 |
| Mascot: | Ram |
Murrieta Mesa High School (MMHS) is a comprehensive, four-year high school located in Murrieta, California, United States. It is operated by the Murrieta Valley Unified School District. The school opened in 2009 to keep up with population growth in Murrieta. The first graduating class was the class of 2012. The school derives its name from the mesa it sits on, identified in an 1884 surveyor's map of the valley.