| Muhambwe | |
| Native Name: | Kata ya Muhambwe |
| Native Name Lang: | sw |
| Settlement Type: | District Division |
| Pushpin Map: | Tanzania#Africa |
| Pushpin Relief: | yes |
| Coordinates: | -3.558°N 30.748°W |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name1: | Kigoma Region |
| Subdivision Type2: | District |
| Subdivision Name2: | Buhigwe District |
| Subdivision Type3: | Division |
| Subdivision Name3: | Muhambwe |
| Leader Title1: | MP |
| Leader Name1: | Atashasta Justus Nditiye |
| Leader Title2: | Chairman |
| Leader Name2: | Simon Kanguye Kagoli |
| Leader Title3: | Councilor |
| Leader Name3: | Julius Charles Kihuna |
| Population As Of: | 2016 |
| Population Total: | 287652 |
| Postal Code: | 474xx |
| Postal Code Type: | Postcode |
| Timezone: | EAT |
| Utc Offset: | +3 |
Muhambwe is an administrative division in Kibondo District of Kigoma Region in Tanzania. In 2016 the Tanzania National Bureau of Statistics report there were 287,652 people in the division.