| Mohammad-Qoli Khan Qajar | |
| Office: | Governor of Karabakh-Ganja (1st term) |
| Office1: | Governor of Karabakh-Ganja (2nd term) |
| Monarch1: | Safi of Persia |
| Blank2: | Tribe |
| Data2: | Qajar |
| Preceded: | Mohammad-Khan b. Khalil Khan Qajar |
| Successor: | Daud Khan Undiladze |
| Termstart: | 1616 |
| Termend: | 1627 |
| Termstart1: | 1633 |
| Termend1: | Unknown |
| Allegiance: | Safavid Iran |
| Successor1: | Morteza-Qoli Qajar |
| Predecessor: | Mohammad-Khan b. Khalil Khan Qajar |
| Predecessor1: | Daud Khan Undiladze |
Mohammad-Qoli Khan Qajar was an Iranian military leader and official, who served as the governor (beglarbeg) of Karabakh and Ganja in 1616-1627 and 1633. He was a son of the previous governor of Karabakh, Mohammad-Khan Qajar (1606–1616), and a member of the Ziyādoghlu branch of the Turkoman Qajar clan. Around 1620, when Paykar Khan Igirmi Durt was given a sister of Lohrasb (Luarsab II of Kartli) by then incumbent king Abbas I (r. 1588-1629) on the occasion of him being appointed as the new governor of Kakheti, Mohammad-Qoli Khan Qajar was given a sister of Tahmuras Khan (Teimuraz I of Kakheti). When in 1624, king Abbas I married his granddaughter to Semayun Khan (Simon II), Abd-ol-Ghaffar's wife was a companion to the bride, while Mohammad-Qoli Khan Qajar ordered Paykar Khan Igirmi Durt to host the banquet in the second term of the wedding party.