Mitochondrial pyruvate carrier explained
The mitochondrial pyruvate carriers are composed of:[1] [2]
The pyruvate carriers are involved in mitochondrial metabolism but it is possible to compensate for their loss of function.[3] They have been studied for a role in cardiac stress adaption.[4]
Notes and References
- McCommis . Kyle S. . Finck . Brian N. . 15 March 2015 . Mitochondrial pyruvate transport: a historical perspective and future research directions . Biochemical Journal . 466 . 3 . 443–454 . 10.1042/BJ20141171 . 4464838 . 25748677.
- Web site: SLC54 Mitochondrial pyruvate carriers Transporters IUPHAR/BPS Guide to PHARMACOLOGY . 3 December 2023 . www.guidetopharmacology.org.
- Bender . Tom . Martinou . Jean-Claude . 1 October 2016 . The mitochondrial pyruvate carrier in health and disease: To carry or not to carry? . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1863 . 10 . 2436–2442 . 10.1016/j.bbamcr.2016.01.017 . 0167-4889 . 26826034.
- Zhang . Yuan . Taufalele . Paul V. . Cochran . Jesse D. . Robillard-Frayne . Isabelle . Marx . Jonas Maximilian . Soto . Jamie . Rauckhorst . Adam J. . Tayyari . Fariba . Pewa . Alvin D. . Gray . Lawrence R. . Teesch . Lynn M. . Puchalska . Patrycja . Funari . Trevor R. . McGlauflin . Rose . Zimmerman . Kathy . November 2020 . Mitochondrial pyruvate carriers are required for myocardial stress adaptation . Nature Metabolism . en . 2 . 11 . 1248–1264 . 10.1038/s42255-020-00288-1 . 2522-5812 . 8015649 . 33106689 . Kutschke . William J. . Cassier . Thomas . Hitchcock . Shannon . Lin . Kevin . Kato . Kevin M. . Stueve . Jennifer L. . Haff . Lauren . Weiss . Robert M. . Cox . James E. . Rutter . Jared . Taylor . Eric B. . Crawford . Peter A. . Lewandowski . E. Douglas . Des Rosiers . Christine . Abel . E. Dale.