Mir-370 microRNA precursor family explained

In molecular biology mir-370 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. This microRNA, mir-370-3p, has been shown to play a role in heart failure. The upregulation of mir-370-3p in the sinus node leads to downregulation of the pacemaker ion channel, HCN4, and thus downregulation of the corresponding ionic current, which causes sinus bradycardia.^[1]

See also

• MicroRNA

Further reading

• Itoh T, Ando M, Tsukamasa Y, Akao Y . Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370 . FEBS Letters . 586 . 12 . 1693–701 . June 2012 . 22587915 . 10.1016/j.febslet.2012.04.014 . free .
• Gao W, He HW, Wang ZM, Zhao H, Lian XQ, Wang YS, Zhu J, Yan JJ, Zhang DG, Yang ZJ, Wang LS . Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease . Lipids in Health and Disease . 11 . 1 . 55 . May 2012 . 22587332 . 3439335 . 10.1186/1476-511X-11-55 . free .
• Mian C, Pennelli G, Fassan M, Balistreri M, Barollo S, Cavedon E, Galuppini F, Pizzi M, Vianello F, Pelizzo MR, Girelli ME, Rugge M, Opocher G. MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: Preliminary relationships with RET status and outcome . Thyroid . 890–6 . 2012 . 22747440 . 3429275 . 10.1089/thy.2012-0045 . 22. 9 .
• Sacco J, Adeli K . MicroRNAs: emerging roles in lipid and lipoprotein metabolism . Current Opinion in Lipidology . 23 . 3 . 220–5 . June 2012 . 22488426 . 10.1097/MOL.0b013e3283534c9f . 23814795 .
• Liu DZ, Ander BP, Tian Y, Stamova B, Jickling GC, Davis RR, Sharp FR . Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells . Gene . 495 . 2 . 120–7 . March 2012 . 22244746 . 10.1016/j.gene.2011.12.041 .
• Lo SS, Hung PS, Chen JH, Tu HF, Fang WL, Chen CY, Chen WT, Gong NR, Wu CW . Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma . Oncogene . 31 . 2 . 226–37 . January 2012 . 21666718 . 10.1038/onc.2011.226 . free .
• Yoshino H, Chiyomaru T, Enokida H, Kawakami K, Tatarano S, Nishiyama K, Nohata N, Seki N, Nakagawa M . The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer . British Journal of Cancer . 104 . 5 . 808–18 . March 2011 . 21304530 . 3048214 . 10.1038/bjc.2011.23 .
• Fernández-Hernando C, Suárez Y, Rayner KJ, Moore KJ . MicroRNAs in lipid metabolism . Current Opinion in Lipidology . 22 . 2 . 86–92 . April 2011 . 21178770 . 3096067 . 10.1097/MOL.0b013e3283428d9d .
• Castilla MÁ, Moreno-Bueno G, Romero-Pérez L, Van De Vijver K, Biscuola M, López-García MÁ, Prat J, Matías-Guiu X, Cano A, Oliva E, Palacios J . Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma . The Journal of Pathology . 223 . 1 . 72–80 . January 2011 . 21125666 . 10.1002/path.2802 . 38007588 .
• Moore KJ, Rayner KJ, Suárez Y, Fernández-Hernando C . microRNAs and cholesterol metabolism . Trends in Endocrinology and Metabolism . 21 . 12 . 699–706 . December 2010 . 20880716 . 2991595 . 10.1016/j.tem.2010.08.008 .
• Hoekstra M, van der Lans CA, Halvorsen B, Gullestad L, Kuiper J, Aukrust P, van Berkel TJ, Biessen EA . The peripheral blood mononuclear cell microRNA signature of coronary artery disease . Biochemical and Biophysical Research Communications . 394 . 3 . 792–7 . April 2010 . 20230787 . 10.1016/j.bbrc.2010.03.075 .
• Iliopoulos D, Drosatos K, Hiyama Y, Goldberg IJ, Zannis VI . MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism . Journal of Lipid Research . 51 . 6 . 1513–23 . June 2010 . 20124555 . 3035515 . 10.1194/jlr.M004812 . free .
• Xu CF, Yu CH, Li YM . Regulation of hepatic microRNA expression in response to ischemic preconditioning following ischemia/reperfusion injury in mice . OMICS . 13 . 6 . 513–20 . December 2009 . 19780683 . 10.1089/omi.2009.0035 .
• Haller F, von Heydebreck A, Zhang JD, Gunawan B, Langer C, Ramadori G, Wiemann S, Sahin O . Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31 . The Journal of Pathology . 220 . 1 . 71–86 . January 2010 . 19768731 . 10.1002/path.2610 . 26480742 .
• Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM . MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats . Clinical and Experimental Pharmacology & Physiology . 36 . 2 . 181–8 . February 2009 . 18986336 . 10.1111/j.1440-1681.2008.05057.x . 205458045 .
• Dixon-McIver A, East P, Mein CA, Cazier JB, Molloy G, Chaplin T, Andrew Lister T, Young BD, Debernardi S . Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia . PLOS ONE . 3 . 5 . e2141 . May 2008 . 18478077 . 2373886 . 10.1371/journal.pone.0002141 . 2008PLoSO...3.2141D . Seoighe . Cathal . free .
• Meng F, Wehbe-Janek H, Henson R, Smith H, Patel T . Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes . Oncogene . 27 . 3 . 378–86 . January 2008 . 17621267 . 10.1038/sj.onc.1210648 . free .

Notes and References

1. Yanni . Joseph . D’Souza . Alicia . Wang . Yanwen . Li . Ning . Hansen . Brian J. . Zakharkin . Stanislav O. . Smith . Matthew . Hayward . Christina . Whitson . Bryan A. . Mohler . Peter J. . Janssen . Paul M. L. . Zeef . Leo . Choudhury . Moinuddin . Zi . Min . Cai . Xue . Logantha . Sunil Jit R. J. . Nakao . Shu . Atkinson . Andrew . Petkova . Maria . Doris . Ursula . Ariyaratnam . Jonathan . Cartwright . Elizabeth J. . Griffiths-Jones . Sam . Hart . George . Fedorov . Vadim V. . Oceandy . Delvac . Dobrzynski . Halina . Boyett . Mark R. . Silencing miR-370-3p rescues funny current and sinus node function in heart failure . Scientific Reports . 9 July 2020 . 10 . 1 . 11279 . 10.1038/s41598-020-67790-0 . 32647133 . 7347645 .