MicC RNA explained
MicC RNA |
Symbol: | MicC |
Altsymbols: | IS063 |
Rfam: | RF00121 |
Rna Type: | Gene
- sRNA
|
Tax Domain: | Bacteria |
The MicC non-coding RNA (previously known as IS063 [1]) is located between the ompN and ydbK genes in E. coli. This Hfq-associated RNA is thought to be a regulator of the expression level of the OmpC porin protein, with a 5′ region of 22 nucleotides potentially forming an antisense interaction with the ompC mRNA. Along with MicF RNA this family may act in conjunction with EnvZ-OmpR two-component system to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli.[2] The expression of micC was shown to be increased in the presence of beta-lactam antibiotics.[3]
See also
Further reading
- Pfeiffer V, Papenfort K, Lucchini S, Hinton JC, Vogel J . Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation . Nature Structural & Molecular Biology . 16 . 8 . 840–846 . August 2009 . 19620966 . 10.1038/nsmb.1631 . 37445410 .
Notes and References
- Chen S, Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, Blyn LB . A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome . Bio Systems . 65 . 2–3 . 157–177 . 2002 . 12069726 . 10.1016/S0303-2647(02)00013-8 .
- Chen S, Zhang A, Blyn LB, Storz G . MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli . Journal of Bacteriology . 186 . 20 . 6689–6697 . October 2004 . 15466019 . 522180 . 10.1128/JB.186.20.6689-6697.2004 .
- Dam S, Pagès JM, Masi M . Dual Regulation of the Small RNA MicC and the Quiescent Porin OmpN in Response to Antibiotic Stress in Escherichia coli . Antibiotics . 6 . 4 . 33 . December 2017 . 29211019 . 5745476 . 10.3390/antibiotics6040033 . free .