MiR-338 explained

miR-338
Symbol:miR-338
Altsymbols:MIR338
Rfam:RF00686
Mirbase:MI0000814
Mirbase Family:MIPF0000097
Rna Type:miRNA
Tax Domain:Mammalia
Go:0035195
So:0001244
Entrezgene:442906
Hgncid:31775
Omim:614059
Refseq:NR_029897
Chromosome:17
Arm:q
Band:25.3

miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans.[1] The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[2] This sequence then associates with RISC which effects RNA interference.[3]

miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression.[4]

Function

miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4).[5] The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing.

Applications

miR-338 is dysregulated in neuroblastoma, and could potentially be implemented as a biomarker or future therapeutic agent.[6] miR-338 has also been linked with hepatocellular carcinoma, and a large-scale diagnostic test has been suggested involving measurement of miR-338 expression in tissue samples.[7] Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer.[8]

Further reading

Notes and References

  1. Aschrafi A, Schwechter AD, Mameza MG, Natera-Naranjo O, Gioio AE, Kaplan BB . MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons . The Journal of Neuroscience . 28 . 47 . 12581–90 . Nov 2008 . 19020050 . 3496265 . 10.1523/JNEUROSCI.3338-08.2008 .
  2. Ambros V . microRNAs: tiny regulators with great potential . Cell . 107 . 7 . 823–6 . Dec 2001 . 11779458 . 10.1016/S0092-8674(01)00616-X . 14574186 . free .
  3. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R . Human RISC couples microRNA biogenesis and posttranscriptional gene silencing . Cell . 123 . 4 . 631–40 . Nov 2005 . 16271387 . 10.1016/j.cell.2005.10.022 . 16973870 . free .
  4. Barik S . An intronic microRNA silences genes that are functionally antagonistic to its host gene . Nucleic Acids Research . 36 . 16 . 5232–41 . Sep 2008 . 18684991 . 2532712 . 10.1093/nar/gkn513 .
  5. Book: Kaplan BB, Gioio AE, Hillefors M, Aschrafi A . Cell Biology of the Axon . Axonal protein synthesis and the regulation of local mitochondrial function . 48 . 225–42 . 2009 . 19343315 . 2786086 . 10.1007/400_2009_1 . 978-3-642-03018-5 . Results and Problems in Cell Differentiation .
  6. Ragusa M, Majorana A, Banelli B, Barbagallo D, Statello L, Casciano I, Guglielmino MR, Duro LR, Scalia M, Magro G, Di Pietro C, Romani M, Purrello M . MIR152, MIR200B, and MIR338, human positional and functional neuroblastoma candidates, are involved in neuroblast differentiation and apoptosis . Journal of Molecular Medicine . 88 . 10 . 1041–53 . Oct 2010 . 20574809 . 10.1007/s00109-010-0643-0 . 22215883 .
  7. Huang XH, Wang Q, Chen JS, Fu XH, Chen XL, Chen LZ, Li W, Bi J, Zhang LJ, Fu Q, Zeng WT, Cao LQ, Tan HX, Su Q . Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated . Hepatology Research . 39 . 8 . 786–94 . Aug 2009 . 19473441 . 10.1111/j.1872-034X.2009.00502.x . 11863697 . free .
  8. Li X, Zhang Y, Zhang Y, Ding J, Wu K, Fan D . Survival prediction of gastric cancer by a seven-microRNA signature . Gut . 59 . 5 . 579–85 . May 2010 . 19951901 . 10.1136/gut.2008.175497 . 25196666 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "MiR-338".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.