| Address: | 2115 Grand Avenue |
| City: | Grand Junction |
| State: | Colorado |
| Zipcode: | 81501 |
| Type: | Public |
| Grades: | PreK–12 |
| Students: | 21,084 (2020–2021) |
| Teachers: | 1,325.88 |
| Staff: | 1,494.24 |
| Ratio: | 15.9:1 |
Mesa County Valley School District 51 is a school district in Mesa County, Colorado, United States. It is the tenth largest school district in the state. It comprises the Grand Junction area.