Membrane-type matrix metalloproteinase-1 explained

Membrane-type matrix metalloproteinase-1 (matrix metalloproteinase 14) is an enzyme.^[1] This enzyme catalyses the following chemical reaction

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn³⁷-Leu. Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn³⁴¹-Phe, Asp⁴⁴¹-Leu and Gln³⁵⁴-Thr in the aggrecan interglobular domain

This enzyme belongs to peptidase family M10.

See also

• Metalloproteinase

Notes and References

1. Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M . Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion . The EMBO Journal . 20 . 17 . 4782–93 . September 2001 . 11532942 . 125610 . 10.1093/emboj/20.17.4782 .