| Mayo-Tsanaga | |
| Settlement Type: | Department |
| Mapsize: | 260px |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Subdivision Type: | Country |
| Subdivision Name: |  Cameroon |
| Subdivision Type1: | Province |
| Subdivision Name1: | Extreme-Nord Province |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Mokolo |
| Unit Pref: | Imperial |
| Area Total Km2: | 4393 |
| Population As Of: | 2005 |
| Population Total: | 699,971 |
| Population Blank1 Title: | Ethnicities |
| Timezone: | WAT |
| Utc Offset: | +1 |
Mayo-Tsanaga is a department of Extreme-Nord Province in Cameroon. The department covers an area of 4,393 km and at the 2005 Census had a total population of 699,971.[1] The capital of the department is at Mokolo. It is located within the Mandara Mountains, on the border with Nigeria.
The department is divided administratively into 7 communes and in turn into villages.