| Mark Twain | |
| Type: | Neighborhood of St. Louis |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Missouri |
| Subdivision Type3: | City |
| Subdivision Name3: | St. Louis |
| Parts Type: | Wards |
| Parts Style: | para |
| P1: | 1, 21 |
| Leader Title: | Aldermen |
| Population Total: | 3,257 |
| Population As Of: | 2020 |
| Population Footnotes: | [1] |
| Area Total Sq Mi: | 0.65 |
| Population Density Sq Mi: | auto |
| Postal Code Type: | ZIP code(s) |
| Postal Code: | Parts of 63115, 63120 |
| Area Code Type: | Area code(s) |
| Area Code: | 314 |
| Website: | stlouis-mo.gov |
Mark Twain is a neighborhood of St. Louis, Missouri named after author and Missouri native Mark Twain. It is located between Interstate 70 and Bellefontaine Cemetery.
In 2020 Mark Twain's racial makeup was 95.1% Black, 2.4% White, 0.2% Native American, 0.3% Asian, 1.4% Two or More Races, and 0.6% Some Other Race. 1.0% of the population was of Hispanic or Latino origin.[2]