| Manuel Bernardo Aguirre | |
| Office: | Governor of Chihuahua |
| Term Start: | 4 October 1974 |
| Term End: | 3 October 1980 |
| Predecessor: | Oscar Flores Sánchez |
| Successor: | Óscar Ornelas |
| Order2: | Senator for Chihuahua |
| Term Start2: | 1 September 1964 |
| Term End2: | 1970 |
| Order3: | Member of the Chamber of Deputies for Chihuahua's 1st district |
| Term Start3: | 1 September 1961 |
| Term End3: | 31 August 1964 |
| Predecessor3: | Miguel Ángel Olea Enríquez |
| Successor3: | Saúl González Herrera |
| Order4: | Member of the Chamber of Deputies for Chihuahua's 4th district |
| Term Start4: | 1 September 1940 |
| Term End4: | 31 August 1943 |
| Predecessor4: | Ismael C. Falcón |
| Successor4: | Guillermo Quevedo Moreno |
| Birth Date: | 20 August 1908 |
| Birth Place: | Baborigame, Chihuahua, Mexico |
| Death Place: | Baborigame, Chihuahua, Mexico |
| Party: | PRI |
Manuel Bernardo Aguirre Samaniego (20 August 1908 – 4 April 1999) was a Mexican politician from the Institutional Revolutionary Party (PRI). He was secretary of agriculture (1970–1974) and governor of Chihuahua (1974–1980).