| Manuel Alves Grande River | |
| Source1 Location: | Tocantins and Maranhão states |
| Mouth: | Tocantins River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
| Length: | 234,87 km[1] |
The Manuel Alves Grande River is a river of Tocantins and Maranhão states, dividing the north and northeast regions of Brazil. It is a tributary of the Tocantins River.