Manganese exporter explained

The Manganese (Mn2+) Exporter (MntP) Family (TC# 2.A.107) is a member of the Lysine Exporter (LysE) Superfamily.^[1] The MntP family is a small family whose members have been found in bacteria and archaea. MntP proteins are of about 200 amino acyl residues with 6 putative transmembrane segments (TMSs). The Conserved Domain Database (CDD) recognized two DUF204 repeats, each repeat having 3 TMSs. A representative list of proteins belonging to the MntP family can be found in the Transporter Classification Database.

Function

At least one member (YebN of E. coli, TC# 2.A.107.1.1) has been shown to function as a putative manganese efflux pump. Manganese sensitivity and intracellular manganese levels significantly increased in bacteria when the mntP (formerly yebN) gene, which encodes the MntP efflux pump, was deleted. While manganese is a highly important trace nutrient for organisms from bacteria to humans, acting as an important element in the defense against oxidative stress and as an enzyme cofactor, it becomes toxic when present in excess.^[2]

See also

• Manganese
• Transporter Classification Database

Further reading

• Martin JE, Waters LS, Storz G, Imlay JA . The Escherichia coli small protein MntS and exporter MntP optimize the intracellular concentration of manganese . PLOS Genetics . 11 . 3 . e1004977 . March 2015 . 25774656 . 4361602 . 10.1371/journal.pgen.1004977 . free .
• Farcasanu IC, Hirata D, Tsuchiya E, Nishiyama F, Miyakawa T . Protein phosphatase 2B of Saccharomyces cerevisiae is required for tolerance to manganese, in blocking the entry of ions into the cells . European Journal of Biochemistry . 232 . 3 . 712–7 . September 1995 . 7588708 . 10.1111/j.1432-1033.1995.712zz.x .
• Book: Amornrat Naranuntarat . Jensen . Laran T. . Jensen . Chapter 1: Manganese Transport, Trafficking and Function in Invertebrates . Lucio . Costa . Michael . Aschner . vanc . Manganese in Health and Disease . Issues in Toxicology . 2014 . 10.1039/9781782622383-00001 . Royal Society of Chemistry . 1–33 . 978-1-84973-943-6 .

External links

• Pfam - MntP
• Uniprot - MntP

Notes and References

1. Tsu BV, Saier MH . The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis . PLOS ONE . 10 . 10 . e0137184 . 2015-01-01 . 26474485 . 4608589 . 10.1371/journal.pone.0137184 . 2015PLoSO..1037184T . free .
2. Waters LS, Sandoval M, Storz G . The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis . Journal of Bacteriology . 193 . 21 . 5887–97 . November 2011 . 21908668 . 3194919 . 10.1128/JB.05872-11 .