| Manampatrana River | |
| Subdivision Type1: | Country |
| Subdivision Name1: | Madagascar |
| Subdivision Type3: | Region |
| Subdivision Name3: | Atsimo-Atsinanana |
| Subdivision Type5: | City |
| Subdivision Name5: | Farafangana |
| Mouth: | Indian Ocean |
| Mouth Location: | Farafangana, Atsimo-Atsinanana |
| Mouth Coordinates: | -22.8194°N 47.8167°W |
| Mouth Elevation: | 0m (00feet) |
| Basin Size: | 3976.52 km2[1] |
| Tributaries Left: | Manambava |
Manampatrana is a river in the region of Atsimo-Atsinanana in south-eastern Madagascar. It has its springs in the Andringitra Massif and flows into the Indian Ocean north of Farafangana.