MYO9B explained

MYO9B is a gene that encodes the Myosin-IXb protein.^{[1] [2]}

Further reading

• Bement WM, Hasson T, Wirth JA, etal . Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 14 . 6549–53 . 1994 . 8022818 . 10.1073/pnas.91.14.6549 . 44240 . 1994PNAS...91.6549B . free .
• Wirth JA, Jensen KA, Post PL, etal . Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. . J. Cell Sci. . 109 . 3. 653–61 . 1997 . 10.1242/jcs.109.3.653 . 8907710 .
• Post PL, Bokoch GM, Mooseker MS . Human myosin-IXb is a mechanochemically active motor and a GAP for rho. . J. Cell Sci. . 111 . 7. 941–50 . 1998 . 10.1242/jcs.111.7.941 . 9490638 .
• Grewal PK, Jones AM, Maconochie M, etal . Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing. . Gene . 240 . 2 . 389–98 . 2000 . 10580159 . 10.1016/S0378-1119(99)00459-X .
• Post PL, Tyska MJ, O'Connell CB, etal . Myosin-IXb is a single-headed and processive motor. . J. Biol. Chem. . 277 . 14 . 11679–83 . 2002 . 11801597 . 10.1074/jbc.M111173200 . free .
• Inoue A, Saito J, Ikebe R, Ikebe M . Myosin IXb is a single-headed minus-end-directed processive motor. . Nat. Cell Biol. . 4 . 4 . 302–6 . 2002 . 11901422 . 10.1038/ncb774 . 12158370 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Van Belzen MJ, Meijer JW, Sandkuijl LA, etal . A major non-HLA locus in celiac disease maps to chromosome 19. . Gastroenterology . 125 . 4 . 1032–41 . 2003 . 14517787 . 10.1016/S0016-5085(03)01205-8 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Saeki N, Tokuo H, Ikebe M . BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. . J. Biol. Chem. . 280 . 11 . 10128–34 . 2005 . 15644318 . 10.1074/jbc.M413415200 . free .
• Cheng J, Kapranov P, Drenkow J, etal . Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. . Science . 308 . 5725 . 1149–54 . 2005 . 15790807 . 10.1126/science.1108625 . 2005Sci...308.1149C . 13047538 .
• Monsuur AJ, de Bakker PI, Alizadeh BZ, etal . Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. . Nat. Genet. . 37 . 12 . 1341–4 . 2006 . 16282976 . 10.1038/ng1680 . 35506194 .
• Kambara T, Ikebe M . A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX. . J. Biol. Chem. . 281 . 8 . 4949–57 . 2006 . 16338935 . 10.1074/jbc.M509141200 . free .
• Nishikawa M, Nishikawa S, Inoue A, etal . A unique mechanism for the processive movement of single-headed myosin-IX. . Biochem. Biophys. Res. Commun. . 343 . 4 . 1159–64 . 2006 . 16616011 . 10.1016/j.bbrc.2006.03.057 .
• Amundsen SS, Monsuur AJ, Wapenaar MC, etal . Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. . Hum. Immunol. . 67 . 4–5 . 341–5 . 2006 . 16720215 . 10.1016/j.humimm.2006.03.020 .
• Giordano M, Marano C, Mellai M, etal . A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population. . Genes Immun. . 7 . 7 . 606–8 . 2007 . 16943798 . 10.1038/sj.gene.6364331 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• van Bodegraven AA, Curley CR, Hunt KA, etal . Genetic variation in myosin IXB is associated with ulcerative colitis. . Gastroenterology . 131 . 6 . 1768–74 . 2007 . 17087940 . 10.1053/j.gastro.2006.09.011 .
• Núñez C, Márquez A, Varadé J, etal . No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population. . Tissue Antigens . 68 . 6 . 489–92 . 2007 . 17176439 . 10.1111/j.1399-0039.2006.00699.x .

Notes and References

1. Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS . Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1 . Genomics . 43 . 1 . 107–9 . Sep 1997 . 9226381 . 10.1006/geno.1997.4776 .
2. Web site: Entrez Gene: MYO9B myosin IXB.