MYO5B explained

Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans.^{[1] [2] [3] [4]}

Recent evidence suggests that Myosin-Vb is related to the creation of memories^[5] by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines.^[6]

Mutations of MYO5B cause microvillus inclusion disease due to defective trafficking of apical and basolateral proteins.

MYO5B has also been associated with bipolar disorder.^[7]

Interactions

MYO5B has been shown to interact with RAB11FIP2.^[8]

Further reading

• Huang WM, Reed-Fourquet L, Wu E, Wu JY . Molecular cloning and amino acid sequence of brain L-glutamate decarboxylase . Proceedings of the National Academy of Sciences of the United States of America . 87 . 21 . 8491–5 . Nov 1990 . 2236059 . 54982 . 10.1073/pnas.87.21.8491 . 1990PNAS...87.8491H . free .
• Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS . Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types . Proceedings of the National Academy of Sciences of the United States of America . 91 . 14 . 6549–53 . Jul 1994 . 8022818 . 44240 . 10.1073/pnas.91.14.6549 . 1994PNAS...91.6549B . free .
• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O . Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain . DNA Research . 6 . 5 . 329–36 . Oct 1999 . 10574461 . 10.1093/dnares/6.5.329 . free .
• Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, Provance DW, Mercer JA, Bähler M, Goldenring JR . Myosin vb is associated with plasma membrane recycling systems . Molecular Biology of the Cell . 12 . 6 . 1843–57 . Jun 2001 . 11408590 . 37346 . 10.1091/mbc.12.6.1843 .
• Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR . Identification and characterization of a family of Rab11-interacting proteins . The Journal of Biological Chemistry . 276 . 42 . 39067–75 . Oct 2001 . 11495908 . 10.1074/jbc.M104831200 . free .
• Hales CM, Vaerman JP, Goldenring JR . Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling . The Journal of Biological Chemistry . 277 . 52 . 50415–21 . Dec 2002 . 12393859 . 10.1074/jbc.M209270200 . free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs . Genome Research . 12 . 11 . 1773–84 . Nov 2002 . 12421765 . 187542 . 10.1101/gr.406902 .
• Fan GH, Lapierre LA, Goldenring JR, Sai J, Richmond A . Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis . Molecular Biology of the Cell . 15 . 5 . 2456–69 . May 2004 . 15004234 . 404037 . 10.1091/mbc.E03-09-0706 .
• Wakabayashi Y, Dutt P, Lippincott-Schwartz J, Arias IM . Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells . Proceedings of the National Academy of Sciences of the United States of America . 102 . 42 . 15087–92 . Oct 2005 . 16214890 . 1257697 . 10.1073/pnas.0503702102 . 2005PNAS..10215087W . free .

External links

• GeneTests/NIH/NCBI/UW information Diarrhea with Microvillus Atrophy 2 DIAR2 Microvillus Inclusion Disease MVID gene testing

Notes and References

1. Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA . Mapping of unconventional myosins in mouse and human . Genomics . 36 . 3 . 431–9 . Sep 1996 . 8884266 . 10.1006/geno.1996.0488 . free .
2. Swiatecka-Urban A, Talebian L, Kanno E, Moreau-Marquis S, Coutermarsh B, Hansen K, Karlson KH, Barnaby R, Cheney RE, Langford GM, Fukuda M, Stanton BA . Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells . The Journal of Biological Chemistry . 282 . 32 . 23725–36 . Aug 2007 . 17462998 . 10.1074/jbc.M608531200 . free .
3. Web site: Entrez Gene: MYO5B myosin VB.
4. Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR. Oct 2008. MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity. Nature Genetics. 40. 10. 1163–5. 10.1038/ng.225. 18724368. 205345488.
5. Web site: DukeHealth.org: Scientists Identify Machinery that Helps Make Memories. 2014-03-25.
6. Wang Z, Edwards JG, Riley N, Provance DW, Karcher R, Li XD, Davison IG, Ikebe M, Mercer JA, Kauer JA, Ehlers MD . Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity . Cell . 135 . 3 . 535–48 . Oct 2008 . 18984164 . 2585749 . 10.1016/j.cell.2008.09.057 .
7. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM . Whole-genome association study of bipolar disorder . Molecular Psychiatry . 13 . 6 . 558–69 . Jun 2008 . 18317468 . 10.1038/sj.mp.4002151 . 3777816 .
8. Hales CM, Vaerman JP, Goldenring JR . Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling . The Journal of Biological Chemistry . 277 . 52 . 50415–21 . Dec 2002 . 12393859 . 10.1074/jbc.M209270200 . free .