MYO18B explained

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.^{[1] [2] [3]}

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.

Further reading

• Yokota J, Nishioka M, Tani M, Kohno T . Genetic alterations responsible for metastatic phenotypes of lung cancer cells . Clin. Exp. Metastasis . 20 . 3 . 189–93 . 2003 . 12741677 . 10.1023/A:1022978932215 . 22741542 .
• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Yanaihara N, Nishioka M, Kohno T, etal . Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer . Int. J. Cancer . 112 . 1 . 150–4 . 2004 . 15305387 . 10.1002/ijc.20339 . 25091930 . free .
• Inoue T, Kon T, Ajima R, etal . MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway . Biochem. Biophys. Res. Commun. . 342 . 3 . 829–34 . 2006 . 16499872 . 10.1016/j.bbrc.2006.02.025 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Edakuni N, Ikuta K, Yano S, etal . Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice . Oncol. Res. . 16 . 5 . 235–43 . 2007 . 10.3727/000000006783981062 . 17294804 .

Notes and References

1. Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J . MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer . Proc Natl Acad Sci U S A . 99 . 19 . 12269–74 . Sep 2002 . 12209013 . 129434 . 10.1073/pnas.192445899 . 2002PNAS...9912269N . free .
2. Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G . Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation . J Mol Biol . 326 . 1 . 137–49 . Jan 2003 . 12547197 . 10.1016/S0022-2836(02)01335-9 .
3. Web site: Entrez Gene: MYO18B myosin XVIIIB.