MTSS1 explained
Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene.[1] [2] [3] True to its name, it codes for a metastasis suppressor.
Further reading
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
- Ishikawa K, Nagase T, Nakajima D, etal . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 4 . 5 . 307–13 . 1998 . 9455477 . 10.1093/dnares/4.5.307 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Woodings JA, Sharp SJ, Machesky LM . MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta . Biochem. J. . 371 . Pt 2 . 463–71 . 2003 . 12570871 . 10.1042/BJ20021962 . 1223315 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Yamagishi A, Masuda M, Ohki T, etal . A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein . J. Biol. Chem. . 279 . 15 . 14929–36 . 2004 . 14752106 . 10.1074/jbc.M309408200 . free .
- Goehler H, Lalowski M, Stelzl U, etal . A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease . Mol. Cell . 15 . 6 . 853–65 . 2004 . 15383276 . 10.1016/j.molcel.2004.09.016 . free .
- Nixdorf S, Grimm MO, Loberg R, etal . Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines . Cancer Lett. . 215 . 2 . 209–20 . 2004 . 15488640 . 10.1016/j.canlet.2004.05.002 .
- Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Callahan CA, Ofstad T, Horng L, etal . MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription . Genes Dev. . 18 . 22 . 2724–9 . 2004 . 15545630 . 10.1101/gad.1221804 . 528890 .
- Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE . Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4 . J. Cell Biol. . 168 . 3 . 453–63 . 2005 . 15684034 . 10.1083/jcb.200409078 . 2171717 .
- Bompard G, Sharp SJ, Freiss G, Machesky LM . Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B . J. Cell Sci. . 118 . Pt 22 . 5393–403 . 2006 . 16280553 . 10.1242/jcs.02640 . free .
- Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
- Utikal J, Gratchev A, Muller-Molinet I, etal . The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation . Int. J. Cancer . 119 . 10 . 2287–93 . 2006 . 16921485 . 10.1002/ijc.22106 . 6700103 . free .
- Ma S, Guan XY, Lee TK, Chan KW . Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma . Hum. Pathol. . 38 . 8 . 1201–6 . 2007 . 17442377 . 10.1016/j.humpath.2007.01.004 .
Notes and References
- Mattila PK, Salminen M, Yamashiro T, Lappalainen P . Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain . J Biol Chem . 278 . 10 . 8452–9 . Mar 2003 . 12482861 . 10.1074/jbc.M212113200 . free .
- Lee YG, Macoska JA, Korenchuk S, Pienta KJ . MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer . Neoplasia . 4 . 4 . 291–4 . Jun 2002 . 12082544 . 1531703 . 10.1038/sj.neo.7900231 .
- Web site: Entrez Gene: MTSS1 metastasis suppressor 1.