MTMR12 explained

Myotubularin related protein 12 is a protein that in humans is encoded by the MTMR12 gene.^[1]

Function

Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA . Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP . Proc. Natl. Acad. Sci. U.S.A. . 100 . 15 . 8660–5 . 2003 . 12847286 . 166368 . 10.1073/pnas.1033097100 . 2003PNAS..100.8660N . free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Ritter BP, Angelo GW, Durner M, Rossy-Fullana E, Carrion-Baralt J, Silverman JM, Bespalova IN . Mutation screening of PDZD2, GOLPH3, and MTMR12 genes in patients with schizophrenia . Psychiatr. Genet. . 22 . 1 . 51–2 . 2012 . 21451436 . 10.1097/YPG.0b013e3283463dd7 .

Notes and References

1. Web site: Entrez Gene: Myotubularin related protein 12. 2017-05-19.