MTFMT explained

Mitochondrial methionyl-tRNA formyltransferase is a protein that in humans is encoded by the MTFMT gene.^[1]

The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA.^[1] Recessive-type mutations in MTFMT have been shown to cause mitochondrial disease.^[2]

Further reading

• Takeuchi N, Kawakami M, Omori A, Ueda T, Spremulli LL, Watanabe K . Mammalian mitochondrial methionyl-tRNA transformylase from bovine liver. Purification, characterization, and gene structure . The Journal of Biological Chemistry . 273 . 24 . 15085–15090 . June 1998 . 9614118 . 10.1074/jbc.273.24.15085 . free .

Notes and References

1. Web site: Entrez Gene: Mitochondrial methionyl-tRNA formyltransferase. 2011-09-20.
2. Tucker EJ, Hershman SG, Köhrer C, Belcher-Timme CA, Patel J, Goldberger OA, Christodoulou J, Silberstein JM, McKenzie M, Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, Mootha VK . Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation . Cell Metabolism . 14 . 3 . 428–434 . September 2011 . 21907147 . 3486727 . 10.1016/j.cmet.2011.07.010 .