MTF1 explained

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.^{[1] [2]}

Function

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).^[3]

Further reading

• Westin G, Schaffner W . A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene . The EMBO Journal . 7 . 12 . 3763–70 . Dec 1988 . 3208749 . 454951 . 10.1002/j.1460-2075.1988.tb03260.x.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Chen X, Chu M, Giedroc DP . MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex . Biochemistry . 38 . 39 . 12915–25 . Sep 1999 . 10504263 . 10.1021/bi9913000 .
• Otsuka F, Okugaito I, Ohsawa M, Iwamatsu A, Suzuki K, Koizumi S . Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1492 . 2–3 . 330–40 . Jul 2000 . 11004505 . 10.1016/s0167-4781(00)00110-x .
• Saydam N, Georgiev O, Nakano MY, Greber UF, Schaffner W . Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals . The Journal of Biological Chemistry . 276 . 27 . 25487–95 . Jul 2001 . 11306562 . 10.1074/jbc.M009154200 . free .
• Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH . Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription . The Journal of Biological Chemistry . 277 . 23 . 20438–45 . Jun 2002 . 11923282 . 10.1074/jbc.M110631200 . free .
• Majumder S, Ghoshal K, Summers D, Bai S, Datta J, Jacob ST . Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1 . The Journal of Biological Chemistry . 278 . 28 . 26216–26 . Jul 2003 . 12716893 . 2365495 . 10.1074/jbc.M302887200 . free .
• Saydam N, Steiner F, Georgiev O, Schaffner W . Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1 . The Journal of Biological Chemistry . 278 . 34 . 31879–83 . Aug 2003 . 12805380 . 10.1074/jbc.M302138200 . free .
• Chen X, Zhang B, Harmon PM, Schaffner W, Peterson DO, Giedroc DP . A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo . The Journal of Biological Chemistry . 279 . 6 . 4515–22 . Feb 2004 . 14610091 . 10.1074/jbc.M308924200 . free .
• Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W . Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison . Biological Chemistry . 385 . 7 . 597–603 . Jul 2004 . 15318808 . 10.1515/BC.2004.074 . 34611525 . free .
• Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S . Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors . Oncogene . 24 . 13 . 2204–17 . Mar 2005 . 15735762 . 10.1038/sj.onc.1208206 . 25970893 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W . Grant Robert Sutherland . Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1 . Nucleic Acids Research . 22 . 15 . 3167–73 . Aug 1994 . 8065932 . 310292 . 10.1093/nar/22.15.3167 .
2. Web site: Entrez Gene: MTF1 metal-regulatory transcription factor 1.
3. Web site: Entrez Gene: MTF1 metal-regulatory transcription factor 1.