MRFAP1 explained

MORF4 family-associated protein 1 is a protein that in humans is encoded by the MRFAP1 gene.^{[1] [2]}

Interactions

MRFAP1 has been shown to interact with MORF4L1^{[3] [4]} and Retinoblastoma protein.^{[3] [4]}

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Zhang P, Zhao J, Wang B, Du J, Lu Y, Chen J, Ding J . The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14 . Protein Science . 15 . 10 . 2423–34 . Oct 2006 . 17008723 . 2242394 . 10.1110/ps.062397806 .
• Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM . MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner . The Journal of Biological Chemistry . 278 . 49 . 49618–24 . Dec 2003 . 14506250 . 10.1074/jbc.M309192200 . free .
• Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM . MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation . The Journal of Biological Chemistry . 277 . 52 . 50860–6 . Dec 2002 . 12397079 . 10.1074/jbc.M203839200 . free .
• Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM . MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 . The Journal of Biological Chemistry . 276 . 42 . 39171–8 . Oct 2001 . 11500496 . 10.1074/jbc.M103435200 . free .

Notes and References

1. Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM . PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice . Molecular and Cellular Biology . 24 . 19 . 8366–73 . Oct 2004 . 15367658 . 516751 . 10.1128/MCB.24.19.8366-8373.2004 .
2. Web site: Entrez Gene: MRFAP1 Mof4 family associated protein 1.
3. Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM . MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 . The Journal of Biological Chemistry . 276 . 42 . 39171–8 . Oct 2001 . 11500496 . 10.1074/jbc.M103435200 . free .
4. Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM . MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation . The Journal of Biological Chemistry . 277 . 52 . 50860–6 . Dec 2002 . 12397079 . 10.1074/jbc.M203839200 . free .