MOBKL1A explained
Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.[1] [2]
Function
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.[1]
See also
Further reading
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791. free .
- Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA . Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. . J. Biol. Chem. . 279 . 34 . 35228–35 . 2004 . 15197186 . 10.1074/jbc.M404542200 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
- Chow A, Hao Y, Yang X . Molecular characterization of human homologs of yeast MOB1. . Int. J. Cancer . 126 . 9 . 2079–89 . 2010 . 19739119 . 10.1002/ijc.24878 . 33688672 . free . 1974/1468 . free .
Notes and References
- Web site: Entrez Gene: MOB1.
- Devroe E, Erdjument-Bromage H, Tempst P, Silver PA . Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases . J. Biol. Chem. . 279 . 23 . 24444–51 . June 2004 . 15067004 . 10.1074/jbc.M401999200 . free .
