MMP17 explained

Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 (MT-MMP 4) is an enzyme that in humans is encoded by the MMP17 gene.^{[1] [2]}

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. MMP17 and MMP25 are to this day the only known GPI-anchored membrane-type MMPs, opposite to the more common transmembrane MMPs. The protein activates MMP2 by cleavage.^[2]

In melanocytic cells MMP17 gene expression may be regulated by MITF.^[3]

Further reading

• Nagase H, Woessner JF . Matrix metalloproteinases. . J. Biol. Chem. . 274 . 31 . 21491–4 . 1999 . 10419448 . 10.1074/jbc.274.31.21491 . free .
• Puente XS, Pendás AM, Llano E, etal . Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. . Cancer Res. . 56 . 5 . 944–9 . 1996 . 8640782 .
• Kajita M, Kinoh H, Ito N, etal . Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. . FEBS Lett. . 457 . 3 . 353–6 . 1999 . 10471807 . 10.1016/S0014-5793(99)01065-0 . 46523417 . free .
• Kolkenbrock H, Essers L, Ulbrich N, Will H . Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase. . Biol. Chem. . 380 . 9 . 1103–8 . 1999 . 10543448 . 10.1515/BC.1999.137 . 11192061 .
• Wang Y, Johnson AR, Ye QZ, Dyer RD . Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. . J. Biol. Chem. . 274 . 46 . 33043–9 . 2000 . 10551873 . 10.1074/jbc.274.46.33043 . free .
• Itoh Y, Kajita M, Kinoh H, etal . Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. . J. Biol. Chem. . 274 . 48 . 34260–6 . 1999 . 10567400 . 10.1074/jbc.274.48.34260 . free .
• Kinoh H, Hayashita H, Kajita M, etal . Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2→q12, respectively, by radiation hybrid and in situ hybridization. . Cytogenet. Cell Genet. . 87 . 1–2 . 97–8 . 2000 . 10640822 . 10.1159/000015402 . 24060884 .
• English WR, Puente XS, Freije JM, etal . Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2. . J. Biol. Chem. . 275 . 19 . 14046–55 . 2000 . 10799478 . 10.1074/jbc.275.19.14046 . free .
• Terp GE, Christensen IT, Jørgensen FS . Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. . J. Biomol. Struct. Dyn. . 17 . 6 . 933–46 . 2000 . 10949161 . 10.1080/07391102.2000.10506582. 1270176 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jung M, Römer A, Keyszer G, etal . mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue. . Prostate . 55 . 2 . 89–98 . 2003 . 12661033 . 10.1002/pros.10194 . 21596144 .
• Gauthier MC, Racine C, Ferland C, etal . Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils. . Int. J. Biochem. Cell Biol. . 35 . 12 . 1667–73 . 2004 . 12962706 . 10.1016/S1357-2725(03)00136-5 .
• Rozanov DV, Hahn-Dantona E, Strickland DK, Strongin AY . The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells. . J. Biol. Chem. . 279 . 6 . 4260–8 . 2004 . 14645246 . 10.1074/jbc.M311569200 . free .
• Gao G, Plaas A, Thompson VP, etal . ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. . J. Biol. Chem. . 279 . 11 . 10042–51 . 2004 . 14701864 . 10.1074/jbc.M312100200 . free .
• Atkinson SJ, Roghi C, Murphy G . MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells. . Biochem. J. . 398 . 1 . 15–22 . 2006 . 16686598 . 10.1042/BJ20060243 . 1525013 .

External links

• The MEROPS online database for peptidases and their inhibitors: M10.017

Notes and References

1. Puente XS, Pendas AM, Llano E, Lopez-Otin C . Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24 . Genomics . 54 . 3 . 578–9 . Feb 1999 . 9878265 . 10.1006/geno.1998.5564 .
2. Web site: Entrez Gene: MMP17 matrix metallopeptidase 17 (membrane-inserted).
3. Hoek KS, Schlegel NC, Eichhoff OM, etal . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res. . 21 . 6 . 665–76 . 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . 24698373 . free .