METTL1 explained

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.^{[1] [2]}

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.

See also

• 7-Methylguanosine

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Alexandrov A, Martzen MR, Phizicky EM . Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. . RNA . 8 . 10 . 1253–66 . 2002 . 12403464 . 10.1017/S1355838202024019 . 1370335 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Izmailova E, Bertley FM, Huang Q, etal . HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. . Nat. Med. . 9 . 2 . 191–7 . 2003 . 12539042 . 10.1038/nm822 . 26145639 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Cartlidge RA, Knebel A, Peggie M, etal . The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. . EMBO J. . 24 . 9 . 1696–705 . 2005 . 15861136 . 10.1038/sj.emboj.7600648 . 1142581 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Bahr A, Hankeln T, Fiedler T, Hegemann J, Schmidt ER . Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation . Genomics . 57 . 3 . 424–8 . Aug 1999 . 10329009 . 10.1006/geno.1999.5780 .
2. Web site: Entrez Gene: METTL1 methyltransferase like 1.