MCRS1 explained

Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene.^{[1] [2] [3]}

Interactions

MCRS1 has been shown to interact with PHC2,^[4] Death associated protein 6,^[5] NOL1, PINX1^[6] and Telomerase reverse transcriptase.^[6]

Further reading

• Lin DY, Shih HM . Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration . The Journal of Biological Chemistry . 277 . 28 . 25446–56 . Jul 2002 . 11948183 . 10.1074/jbc.M200633200 . free .
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . Jan 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M . Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length . Biochemical and Biophysical Research Communications . 316 . 4 . 1116–23 . Apr 2004 . 15044100 . 10.1016/j.bbrc.2004.02.166 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP . Phosphoproteomic analysis of the developing mouse brain . Molecular & Cellular Proteomics . 3 . 11 . 1093–101 . Nov 2004 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Shimono K, Shimono Y, Shimokata K, Ishiguro N, Takahashi M . Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription . The Journal of Biological Chemistry . 280 . 47 . 39436–47 . Nov 2005 . 16186106 . 10.1074/jbc.M507356200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Hirohashi Y, Wang Q, Liu Q, Du X, Zhang H, Sato N, Greene MI . p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability . Oncogene . 25 . 35 . 4937–46 . Aug 2006 . 16547491 . 10.1038/sj.onc.1209500 . free .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–6 . Apr 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .
• Davidovic L, Bechara E, Gravel M, Jaglin XH, Tremblay S, Sik A, Bardoni B, Khandjian EW . The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons . Human Molecular Genetics . 15 . 9 . 1525–38 . May 2006 . 16571602 . 10.1093/hmg/ddl074 . free .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . Oct 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Du X, Wang Q, Hirohashi Y, Greene MI . DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription . Experimental and Molecular Pathology . 81 . 3 . 184–90 . Dec 2006 . 17014843 . 10.1016/j.yexmp.2006.07.008 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Zhang J, Liu J, Li X, Li F, Wang L, Zhang J, Liu X, Shen L, Liu N, Deng Y, Yang A, Han H, Zhao M, Yao L . The physical and functional interaction of NDRG2 with MSP58 in cells . Biochemical and Biophysical Research Communications . 352 . 1 . 6–11 . Jan 2007 . 17109818 . 10.1016/j.bbrc.2006.10.141 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Bruni R, Roizman B . Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells . Journal of Virology . 72 . 11 . 8525–31 . Nov 1998 . 9765390 . 110262 . 10.1128/JVI.72.11.8525-8531.1998.
2. Ren Y, Busch RK, Perlaky L, Busch H . The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120 . European Journal of Biochemistry . 253 . 3 . 734–42 . May 1998 . 9654073 . 10.1046/j.1432-1327.1998.2530734.x . free .
3. Web site: Entrez Gene: MCRS1 microspherule protein 1.
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
5. Lin DY, Shih HM . Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration . The Journal of Biological Chemistry . 277 . 28 . 25446–56 . Jul 2002 . 11948183 . 10.1074/jbc.M200633200 . free .
6. Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M . Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length . Biochemical and Biophysical Research Communications . 316 . 4 . 1116–23 . Apr 2004 . 15044100 . 10.1016/j.bbrc.2004.02.166 .