MAS1 oncogene explained
| MAS1 oncogene |
| Hgncid: | 6899 |
| Symbol: | MAS1 |
| Entrezgene: | 4142 |
| Omim: | 165180 |
| Refseq: | NM_002377 |
| Uniprot: | P04201 |
| Chromosome: | 6 |
| Arm: | q |
| Band: | 24 |
| Locussupplementarydata: | -q27 |
| MAS1 oncogene-like |
| Hgncid: | 13961 |
| Symbol: | MAS1L |
| Entrezgene: | 116511 |
| Omim: | 607235 |
| Refseq: | NM_052967 |
| Uniprot: | P35410 |
| Chromosome: | 6 |
| Arm: | p |
| Band: | 21 |
The MAS1 oncogene (MAS receptor) is a G protein-coupled receptor[1] [2] which binds the angiotensin II metabolite angiotensin (1-7).[3] [4] The MAS1 receptor, when activated by binding angiotensin-(1-7), opposes many of the effects of the angiotensin II receptor. Hence, MAS1 receptor agonists have similar therapeutic effects to angiotensin II receptor antagonists, including lowering of blood pressure.[5]
External links
Notes and References
- Nunes-Silva A, Rocha GC, Magalhaes DM, Vaz LN, Salviano de Faria MH, Simoes e Silva AC . Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System . Protein and Peptide Letters . 24 . 9 . 809–816 . November 2017 . 28758593 . 10.2174/0929866524666170728151401 . Bentham Science Publishers Ltd. . (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation, anti-hypertrophy, cardioprotective and renoprotective actions. .
- Young D, Waitches G, Birchmeier C, Fasano O, Wigler M . Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains . Cell . 45 . 5 . 711–9 . June 1986 . 3708691 . 10.1016/0092-8674(86)90785-3 . 29886272 .
- Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T . 6 . Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas . Proceedings of the National Academy of Sciences of the United States of America . 100 . 14 . 8258–63 . July 2003 . 12829792 . 166216 . 10.1073/pnas.1432869100 . 2003PNAS..100.8258S . free .
- Santos RA, Ferreira AJ . Angiotensin-(1-7) and the renin-angiotensin system . Current Opinion in Nephrology and Hypertension . 16 . 2 . 122–8 . March 2007 . 17293687 . 10.1097/MNH.0b013e328031f362 . 32812104 .
- Santos RA, Ferreira AJ . Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist . Cardiovascular Drug Reviews . 24 . 3–4 . 239–46 . 2006 . 17214600 . 10.1111/j.1527-3466.2006.00239.x . free .
