MARCH6 explained

E3 ubiquitin-protein ligase MARCH6 is an enzyme that in humans is encoded by the MARCH6 gene.^{[1] [2]}

Gene name error in Excel

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH6 gene in Microsoft Excel.^[3] This is due to Excel's autocorrect feature treating the text "MARCH6" as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.^[4] The issue can be prevented by using an alias name (such as MARCHF6), prepending with an apostrophe ('), or preformatting the cell as text.

See also

• List of EC numbers (EC 3)

Further reading

• Kreft SG, Wang L, Hochstrasser M . Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). . J. Biol. Chem. . 281 . 8 . 4646–53 . 2006 . 16373356 . 10.1074/jbc.M512215200 . free .
• Hassink G, Kikkert M, van Voorden S, etal . TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. . Biochem. J. . 388 . Pt 2 . 647–55 . 2005 . 15673284 . 10.1042/BJ20041241 . 1138973 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Swanson R, Locher M, Hochstrasser M . A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. . Genes Dev. . 15 . 20 . 2660–74 . 2001 . 11641273 . 10.1101/gad.933301 . 312819 .
• Nagase T, Ishikawa K, Miyajima N, etal . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 5 . 1 . 31–9 . 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .

Notes and References

1. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K . Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins . J Virol . 78 . 3 . 1109–20 . Jan 2004 . 14722266 . 321412 . 10.1128/JVI.78.3.1109-1120.2004 .
2. Web site: Entrez Gene: MARCH6 membrane-associated ring finger (C3HC4) 6.
3. Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, Barrett JC, Weinstein JN . 6 . Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics . BMC Bioinformatics . 5 . 1 . 80 . June 2004 . 15214961 . 459209 . 10.1186/1471-2105-5-80 . free .
4. Ziemann M, Eren Y, El-Osta A . Gene name errors are widespread in the scientific literature . Genome Biology . 17 . 1 . 177 . August 2016 . 27552985 . 4994289 . 10.1186/s13059-016-1044-7 . free .