MAPK8IP3 explained

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.^{[1] [2] [3]}

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[3]

Interactions

MAPK8IP3 has been shown to interact with ASK1,^[4] C-Raf,^[5] PTK2,^[6] MAPK10,^{[1] [4]} Mitogen-activated protein kinase 9,^{[1] [2]} MAPK8,^{[1] [2]} MAP2K1,^{[1] [5]} KLC2,^[7] MAP2K7,^{[2] [4]} KLC1,^[7] MAPK8IP2^[2] and MAP2K4.^{[1] [4]}

Further reading

• Kikuno R, Nagase T, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 3 . 197–205 . 1999 . 10470851 . 10.1093/dnares/6.3.197 . free .
• Kuboki Y, Ito M, Takamatsu N, etal . A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. . J. Biol. Chem. . 275 . 51 . 39815–8 . 2001 . 11044439 . 10.1074/jbc.C000403200 . free .
• Bowman AB, Kamal A, Ritchings BW, etal . Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. . Cell . 103 . 4 . 583–94 . 2001 . 11106729 . 10.1016/S0092-8674(00)00162-8 . 247102 . free .
• Daniels RJ, Peden JF, Lloyd C, etal . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .
• Hattori A, Okumura K, Nagase T, etal . Characterization of long cDNA clones from human adult spleen. . DNA Res. . 7 . 6 . 357–66 . 2001 . 11214971 . 10.1093/dnares/7.6.357 . free .
• Akechi M, Ito M, Uemura K, etal . Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system. . Neurosci. Res. . 39 . 4 . 391–400 . 2001 . 11274738 . 10.1016/S0168-0102(01)00194-8 . 37577286 .
• Byrd DT, Kawasaki M, Walcoff M, etal . UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. . Neuron . 32 . 5 . 787–800 . 2002 . 11738026 . 10.1016/S0896-6273(01)00532-3 . 16942260 . free .
• Matsuura H, Nishitoh H, Takeda K, etal . Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. . J. Biol. Chem. . 277 . 43 . 40703–9 . 2002 . 12189133 . 10.1074/jbc.M202004200 . free . 2297/2692 . free .
• Takino T, Yoshioka K, Miyamori H, etal . A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. . Oncogene . 21 . 42 . 6488–97 . 2002 . 12226752 . 10.1038/sj.onc.1205840 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Morita N, Iizuka K, Murakami T, Kawaguchi H . N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress. . Mol. Cell. Biochem. . 262 . 1–2 . 71–8 . 2005 . 15532711 . 10.1023/B:MCBI.0000038218.09259.1c . 23799480 .
• Martin J, Han C, Gordon LA, etal . The sequence and analysis of duplication-rich human chromosome 16. . Nature . 432 . 7020 . 988–94 . 2005 . 15616553 . 10.1038/nature03187 . 2004Natur.432..988M . free .
• Song JJ, Lee YJ . Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. . J. Biol. Chem. . 280 . 29 . 26845–55 . 2005 . 15911620 . 10.1074/jbc.M502318200 . free .
• Takino T, Nakada M, Miyamori H, etal . JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. . J. Biol. Chem. . 280 . 45 . 37772–81 . 2006 . 16141199 . 10.1074/jbc.M505241200 . free .
• Oh JH, Yang JO, Hahn Y, etal . Transcriptome analysis of human gastric cancer. . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .

Notes and References

1. Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI . JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway . Mol Cell Biol . 19 . 11 . 7539–48 . November 1999 . 10523642 . 84763 . 10.1128/mcb.19.11.7539.
2. Kelkar N, Gupta S, Dickens M, Davis RJ . Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3 . Mol Cell Biol . 20 . 3 . 1030–43 . February 2000 . 10629060 . 85220 . 10.1128/MCB.20.3.1030-1043.2000 .
3. Web site: Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3.
4. Matsuura . Hiroshi . Nishitoh Hideki . Takeda Kohsuke . Matsuzawa Atsushi . Amagasa Teruo . Ito Michihiko . Yoshioka Katsuji . Ichijo Hidenori . October 2002 . Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade . J. Biol. Chem. . 277 . 43 . 40703–9 . United States. 0021-9258. 12189133 . 10.1074/jbc.M202004200 . free . 2297/2692 . free .
5. Kuboki . Y . Ito M . Takamatsu N . Yamamoto K I . Shiba T . Yoshioka K . December 2000 . A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways . J. Biol. Chem. . 275 . 51 . 39815–8 . UNITED STATES. 0021-9258. 11044439 . 10.1074/jbc.C000403200 . free .
6. Takino . Takahisa . Yoshioka Katsuji . Miyamori Hisashi . Yamada Kenneth M . Sato Hiroshi . September 2002 . A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated . Oncogene . 21 . 42 . 6488–97 . England. 0950-9232. 12226752 . 10.1038/sj.onc.1205840 . free .
7. 10.1016/S0092-8674(00)00162-8 . Bowman . A B . Kamal A . Ritchings B W . Philp A V . McGrail M . Gindhart J G . Goldstein L S . November 2000 . Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein . Cell . 103 . 4 . 583–94 . UNITED STATES. 0092-8674. 11106729 . 247102 . free .