MAPK8IP1 explained

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.^{[1] [2]}

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.^[3]

Interactions

MAPK8IP1 has been shown to interact with MAP3K10,^[4] DUSP16,^[5] Mitogen-activated protein kinase 9,^{[4] [6]} MAPK8,^{[6] [7]} LRP2,^{[8] [9]} LRP1,^[8] MAP3K12,^[4] MAP2K7,^[4] MAPK8IP2^[4] and MAP3K11.^[4]

Further reading

• Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . Wentland MA . Ricafrente JY . Liu . W . Gibbs . RA .
• Yu W . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . Andersson B . Worley KC . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
• Whitmarsh AJ . A mammalian scaffold complex that selectively mediates MAP kinase activation . Science . 281 . 5383 . 1671–4 . 1998 . 9733513 . 10.1126/science.281.5383.1671 . Cavanagh J . Tournier C . Yasuda . J . Davis . RJ . 1998Sci...281.1671W .
• Mooser V . Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun –amino-terminal kinase interacting protein-1 (JIP-1) gene . Genomics . 55 . 2 . 202–8 . 1999 . 9933567 . 10.1006/geno.1998.5641 . Maillard A . Bonny C . Steinmann . Myriam . Shaw . Philipp . Yarnall . David P. . Burns . Daniel K. . Schorderet . Daniel F. . Nicod . Pascal .
• Yasuda J . The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins . Mol. Cell. Biol. . 19 . 10 . 7245–54 . 2000 . 10490659 . 10.1128/mcb.19.10.7245. 84717 . Whitmarsh AJ . Cavanagh J . Sharma . M . Davis . RJ .
• Meyer D, Liu A, Margolis B . Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons . J. Biol. Chem. . 274 . 49 . 35113–8 . 2000 . 10574993 . 10.1074/jbc.274.49.35113 . free .
• Kelkar N, Gupta S, Dickens M, Davis RJ . Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 . Mol. Cell. Biol. . 20 . 3 . 1030–43 . 2000 . 10629060 . 10.1128/MCB.20.3.1030-1043.2000 . 85220 .
• Waeber G . The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes . Nat. Genet. . 24 . 3 . 291–5 . 2000 . 10700186 . 10.1038/73523 . Delplanque J . Bonny C . Mooser . Vincent . Steinmann . Myriam . Widmann . Christian . Maillard . Anne . Miklossy . Judith . Dina . Christian . 5964917 .
• Bonny C . IB1 reduces cytokine-induced apoptosis of insulin-secreting cells . J. Biol. Chem. . 275 . 22 . 16466–72 . 2000 . 10748095 . 10.1074/jbc.M908297199 . Oberson A . Steinmann M . Schorderet . DF . Nicod . P . Waeber . G . free.
• Gotthardt M . Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction . J. Biol. Chem. . 275 . 33 . 25616–24 . 2000 . 10827173 . 10.1074/jbc.M000955200 . Trommsdorff M . Nevitt MF . Shelton . J . Richardson . JA . Stockinger . W . Nimpf . J . Herz . J . free .
• Bonny C . Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death . Diabetes . 50 . 1 . 77–82 . 2001 . 11147798 . 10.2337/diabetes.50.1.77 . Oberson A . Negri S . Sauser . C. . Schorderet . D. F. . free.
• Verhey KJ . Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules . J. Cell Biol. . 152 . 5 . 959–70 . 2001 . 11238452 . 10.1083/jcb.152.5.959 . 2198804 . Meyer D . Deehan R . Blenis . J. . Schnapp . B. J. . Rapoport . T. A. . Margolis . B. .
• Matsuda S . c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK . J. Neurosci. . 21 . 17 . 6597–607 . 2001 . 11517249 . 10.1523/JNEUROSCI.21-17-06597.2001. Yasukawa T . Homma Y . Ito . Y . Niikura . T . Hiraki . T . Hirai . S . Ohno . S . Kita . Y . 6763068 . free .
• Abderrahmani A . The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1) . Mol. Cell. Biol. . 21 . 21 . 7256–67 . 2001 . 11585908 . 10.1128/MCB.21.21.7256-7267.2001 . 99900 . Steinmann M . Plaisance V . Niederhauser . G. . Haefliger . J.-A. . Mooser . V. . Bonny . C. . Nicod . P. . Waeber . G. .
• Cai Y . Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation . J. Biol. Chem. . 277 . 2 . 1217–22 . 2002 . 11700324 . 10.1074/jbc.M109663200 . Lechner MS . Nihalani D . Prindle . MJ . Holzman . LB . Dressler . GR . free.
• Scheinfeld MH . Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP) . J. Biol. Chem. . 277 . 5 . 3767–75 . 2002 . 11724784 . 10.1074/jbc.M108357200 . Roncarati R . Vito P . Lopez . PA . Abdallah . M . d'Adamio . L . free.
• Ikeda A . Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway . J. Biochem. . 130 . 6 . 773–81 . 2002 . 11726277 . 10.1093/oxfordjournals.jbchem.a003048. Hasegawa K . Masaki M . Moriguchi . T . Nishida . E . Kozutsumi . Y . Oka . S . Kawasaki . T .
• Hashimoto M . alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells . J. Biol. Chem. . 277 . 13 . 11465–72 . 2002 . 11790792 . 10.1074/jbc.M111428200 . Hsu LJ . Rockenstein E . Takenouchi . T . Mallory . M . Masliah . E . free.

Notes and References

1. Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ . A cytoplasmic inhibitor of the JNK signal transduction pathway . Science . 277 . 5326 . 693–6 . August 1997 . 9235893 . 10.1126/science.277.5326.693 . free .
2. Bonny C, Nicod P, Waeber G . IB1, a JIP-1-related nuclear protein present in insulin-secreting cells . J Biol Chem . 273 . 4 . 1843–6 . March 1998 . 9442013 . 10.1074/jbc.273.4.1843 . free .
3. Web site: Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1.
4. Yasuda . J . Whitmarsh A J . Cavanagh J . Sharma M . Davis R J . October 1999 . The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins . Mol. Cell. Biol. . 19 . 10 . 7245–54 . 0270-7306. 10490659 . 84717 . 10.1128/mcb.19.10.7245.
5. Willoughby . Emma A . Perkins Gordon R . Collins Mary K . Whitmarsh Alan J . March 2003 . The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK . J. Biol. Chem. . 278 . 12 . 10731–6 . 0021-9258. 12524447 . 10.1074/jbc.M207324200 . free .
6. Whitmarsh . A J . Cavanagh J . Tournier C . Yasuda J . Davis R J . September 1998 . A mammalian scaffold complex that selectively mediates MAP kinase activation . . 281 . 5383 . 1671–4 . 0036-8075. 9733513 . 10.1126/science.281.5383.1671. 1998Sci...281.1671W .
7. Cai . Yi . Lechner Mark S . Nihalani Deepak . Prindle Marc J . Holzman Lawrence B . Dressler Gregory R . January 2002 . Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation . J. Biol. Chem. . 277 . 2 . 1217–22 . 0021-9258. 11700324 . 10.1074/jbc.M109663200 . free .
8. Gotthardt . M . Trommsdorff M . Nevitt M F . Shelton J . Richardson J A . Stockinger W . Nimpf J . Herz J . August 2000 . Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction . J. Biol. Chem. . 275 . 33 . 25616–24 . 0021-9258. 10827173 . 10.1074/jbc.M000955200 . free .
9. Petersen . Helle Heibroch . Hilpert Jan . Militz Daniel . Zandler Valerie . Jacobsen Christian . Roebroek Anton J M . Willnow Thomas E . February 2003 . Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule . J. Cell Sci. . 116 . Pt 3 . 453–61 . 0021-9533. 12508107 . 10.1242/jcs.00243 . free .