MAN2A1 explained

Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.^{[1] [2] [3]}

Function

This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi apparatus and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-linked glycosylation) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.

Further reading

• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum . Biochimie . 83 . 8 . 783–90 . Aug 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1 . 1874/5091 . 13576808 . free .
• Dedera DA, Gu RL, Ratner L . Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function . Virology . 187 . 1 . 377–82 . Mar 1992 . 1736542 . 10.1016/0042-6822(92)90331-I .
• Moremen KW, Touster O, Robbins PW . Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme . The Journal of Biological Chemistry . 266 . 25 . 16876–85 . Sep 1991 . 10.1016/S0021-9258(18)55384-9 . 1885615 . Oscar Touster . free .
• Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG . Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 . AIDS Research and Human Retroviruses . 6 . 3 . 371–80 . Mar 1990 . 2187500 . 10.1089/aid.1990.6.371 .
• Shimizu H, Tsuchie H, Honma H, Yoshida K, Tsuruoka T, Ushijima H, Kitamura T . Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins . Japanese Journal of Medical Science & Biology . 43 . 3 . 75–87 . Jun 1990 . 2283726 . 10.7883/yoken1952.43.75 . free .
• Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ . Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells . The Journal of Biological Chemistry . 265 . 18 . 10373–82 . Jun 1990 . 10.1016/S0021-9258(18)86956-3 . 2355006 . free .
• Pal R, Hoke GM, Sarngadharan MG . Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 . Proceedings of the National Academy of Sciences of the United States of America . 86 . 9 . 3384–8 . May 1989 . 2541446 . 287137 . 10.1073/pnas.86.9.3384 . 1989PNAS...86.3384P . free .
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP . Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport . Journal of Virology . 63 . 6 . 2452–6 . Jun 1989 . 2542563 . 250699 . 10.1128/jvi.63.6.2452-2456.1989.
• Kozarsky K, Penman M, Basiripour L, Haseltine W, Sodroski J, Krieger M . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein . Journal of Acquired Immune Deficiency Syndromes . 2 . 2 . 163–9 . 1989 . 2649653 .
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis . AIDS Research and Human Retroviruses . 3 . 3 . 265–82 . 1988 . 2829950 . 10.1089/aid.1987.3.265 .
• Blough HA, Pauwels R, De Clercq E, Cogniaux J, Sprecher-Goldberger S, Thiry L . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins . Biochemical and Biophysical Research Communications . 141 . 1 . 33–8 . Nov 1986 . 3099781 . 10.1016/S0006-291X(86)80330-8 .
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 . Proceedings of the National Academy of Sciences of the United States of America . 85 . 23 . 9248–52 . Dec 1988 . 3264072 . 282716 . 10.1073/pnas.85.23.9248 . 1988PNAS...85.9248M . free .
• Moremen KW, Touster O . Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells . The Journal of Biological Chemistry . 260 . 11 . 6654–62 . Jun 1985 . 10.1016/S0021-9258(18)88830-5 . 3922977 . free .
• Fenouillet E, Jones I, Powell B, Schmitt D, Kieny MP, Gluckman JC . Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain . Journal of Virology . 67 . 1 . 150–60 . Jan 1993 . 8093218 . 237347 . 10.1128/jvi.67.1.150-160.1993.
• Yeh JC, Seals JR, Murphy CI, van Halbeek H, Cummings RD . Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system . Biochemistry . 32 . 41 . 11087–99 . Oct 1993 . 8218172 . 10.1021/bi00092a019 .
• Velasco A, Hendricks L, Moremen KW, Tulsiani DR, Touster O, Farquhar MG . Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II . The Journal of Cell Biology . 122 . 1 . 39–51 . Jul 1993 . 8314846 . 2119607 . 10.1083/jcb.122.1.39 .
• Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN . Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme . Proceedings of the National Academy of Sciences of the United States of America . 92 . 25 . 11766–70 . Dec 1995 . 8524845 . 40483 . 10.1073/pnas.92.25.11766 . 1995PNAS...9211766M . free .
• Bolmstedt A, Sjölander S, Hansen JE, Akerblom L, Hemming A, Hu SL, Morein B, Olofsson S . Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response . Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology . 12 . 3 . 213–20 . Jul 1996 . 8673525 . 10.1097/00042560-199607000-00001 . free .
• Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y . Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface . Journal of Virology . 70 . 11 . 7462–70 . Nov 1996 . 8892864 . 190813 . 10.1128/jvi.70.11.7462-7470.1996.

Notes and References

1. Moremen KW, Robbins PW . Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans . The Journal of Cell Biology . 115 . 6 . 1521–34 . Dec 1991 . 1757461 . 2289207 . 10.1083/jcb.115.6.1521 .
2. Oka T, Ungar D, Hughson FM, Krieger M . The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins . Molecular Biology of the Cell . 15 . 5 . 2423–35 . May 2004 . 15004235 . 404034 . 10.1091/mbc.E03-09-0699 .
3. Web site: Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1.