MAF (gene) explained

Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that in humans is encoded by the MAF gene.^{[1] [2]}

Types

One type, MafA, also known as RIPE3b1,^[3] promotes pancreatic development, as well as insulin gene transcription.^[4]

Interactions

MAF has been shown to interact with:

• • CREBBP EP300^[5]
• MYB^[6]
• SOX9.^[7]

Further reading

• Kerppola TK, Curran T . Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun . Oncogene . 9 . 3 . 675–84 . Mar 1994 . 8108109 .
• Kurschner C, Morgan JI . USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity . Biochemical and Biophysical Research Communications . 231 . 2 . 333–9 . Feb 1997 . 9070273 . 10.1006/bbrc.1997.6097 .
• Hedge SP, Kumar A, Kurschner C, Shapiro LH . c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation . Molecular and Cellular Biology . 18 . 5 . 2729–37 . May 1998 . 9566892 . 110652 . 10.1128/MCB.18.5.2729.
• Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schröck E, Ried T, Kuehl WM . Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma . Blood . 91 . 12 . 4457–63 . Jun 1998 . 9616139 . 10.1182/blood.V91.12.4457. 14835515 .
• Christodoulopoulos P, Cameron L, Nakamura Y, Lemière C, Muro S, Dugas M, Boulet LP, Laviolette M, Olivenstein R, Hamid Q . TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression . The Journal of Allergy and Clinical Immunology . 107 . 4 . 586–91 . Apr 2001 . 11295643 . 10.1067/mai.2001.114883 . free .
• Jamieson RV, Perveen R, Kerr B, Carette M, Yardley J, Heon E, Wirth MG, van Heyningen V, Donnai D, Munier F, Black GC . Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma . Human Molecular Genetics . 11 . 1 . 33–42 . Jan 2002 . 11772997 . 10.1093/hmg/11.1.33 . free .
• Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA . CREB-binding protein/p300 co-activation of crystallin gene expression . The Journal of Biological Chemistry . 277 . 27 . 24081–9 . Jul 2002 . 11943779 . 10.1074/jbc.M201821200 . free .
• Dhakshinamoorthy S, Jaiswal AK . c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction . Oncogene . 21 . 34 . 5301–12 . Aug 2002 . 12149651 . 10.1038/sj.onc.1205642 . free .
• Cousins DJ, Lee TH, Staynov DZ . Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines . Journal of Immunology . 169 . 5 . 2498–506 . Sep 2002 . 12193719 . 10.4049/jimmunol.169.5.2498 . free .
• Huang W, Lu N, Eberspaecher H, De Crombrugghe B . A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene . The Journal of Biological Chemistry . 277 . 52 . 50668–75 . Dec 2002 . 12381733 . 10.1074/jbc.M206544200 . free .
• DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG . Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice . Molecular Vision . 9 . 288–94 . Jun 2003 . 12835653 .
• Grimbert P, Valanciute A, Audard V, Pawlak A, Le gouvelo S, Lang P, Niaudet P, Bensman A, Guellaën G, Sahali D . Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization . The Journal of Experimental Medicine . 198 . 5 . 797–807 . Sep 2003 . 12939343 . 1865475 . 10.1084/jem.20030566 .
• Valanciuté A, le Gouvello S, Solhonne B, Pawlak A, Grimbert P, Lyonnet L, Hue S, Lang P, Remy P, Salomon R, Bensman A, Guellaën G, Sahali D . NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome . Journal of Immunology . 172 . 1 . 688–98 . Jan 2004 . 14688382 . 10.4049/jimmunol.172.1.688 . free .
• Rasmussen T, Knudsen LM, Dahl IM, Johnsen HE . C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance . Leukemia & Lymphoma . 44 . 10 . 1761–6 . Oct 2003 . 14692531 . 10.1080/1042819031000111035 . 3191366 .
• Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM . Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma . Cancer Cell . 5 . 2 . 191–9 . Feb 2004 . 14998494 . 10.1016/S1535-6108(04)00019-4 . free .
• Cao S, Liu J, Song L, Ma X . The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages . Journal of Immunology . 174 . 6 . 3484–92 . Mar 2005 . 15749884 . 2955976 . 10.4049/jimmunol.174.6.3484 .
• Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y, Yamada A, Maeda A, Matsuno F, Hata H, Suzuki A, Imagawa S, Mitsuya H, Esumi H, Koyama A, Yamamoto M, Mori N, Takahashi S . Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human . Cancer Research . 66 . 2 . 812–9 . Jan 2006 . 16424013 . 10.1158/0008-5472.CAN-05-2154 . free .
• Vanita V, Singh D, Robinson PN, Sperling K, Singh JR . A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family . American Journal of Medical Genetics Part A . 140 . 6 . 558–66 . Mar 2006 . 16470690 . 10.1002/ajmg.a.31126 . 13734492 .

Notes and References

1. Web site: Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian).
2. Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S . v-maf, a viral oncogene that encodes a "leucine zipper" motif . Proceedings of the National Academy of Sciences of the United States of America . 86 . 20 . 7711–5 . Oct 1989 . 2554284 . 298140 . 10.1073/pnas.86.20.7711 . 1989PNAS...86.7711N . free .
3. Olbrot M, Rud J, Moss LG, Sharma A . Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA . Proceedings of the National Academy of Sciences of the United States of America . 99 . 10 . 6737–42 . May 2002 . 12011435 . 124472 . 10.1073/pnas.102168499 . 2002PNAS...99.6737O . free .
4. Melloul D, Marshak S, Cerasi E . Regulation of insulin gene transcription . Diabetologia . 45 . 3 . 309–26 . Mar 2002 . 11914736 . 10.1007/s00125-001-0728-y . free .
5. Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA . CREB-binding protein/p300 co-activation of crystallin gene expression . The Journal of Biological Chemistry . 277 . 27 . 24081–9 . Jul 2002 . 11943779 . 10.1074/jbc.M201821200 . free .
6. Hedge SP, Kumar A, Kurschner C, Shapiro LH . c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation . Molecular and Cellular Biology . 18 . 5 . 2729–37 . May 1998 . 9566892 . 110652 . 10.1128/MCB.18.5.2729.
7. Huang W, Lu N, Eberspaecher H, De Crombrugghe B . A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene . The Journal of Biological Chemistry . 277 . 52 . 50668–75 . Dec 2002 . 12381733 . 10.1074/jbc.M206544200 . free .