LPAR5 explained

Lysophosphatidic acid receptor 5 also known as LPA₅ is a protein that in humans is encoded by the LPAR5 gene.^{[1] [2] [3] [4] [5]} LPA₅ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[6]

See also

• Lysophospholipid receptor

Further reading

• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S . Identification of G protein-coupled receptor genes from the human genome sequence . FEBS Letters . 520 . 1-3 . 97–101 . June 2002 . 12044878 . 10.1016/S0014-5793(02)02775-8 . 7116392 . free .

Notes and References

1. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 . Nature Genetics . 26 . 3 . 345–348 . November 2000 . 11062477 . 10.1038/81664 . 38870810 .
2. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF . Discovery and mapping of ten novel G protein-coupled receptor genes . Gene . 275 . 1 . 83–91 . September 2001 . 11574155 . 10.1016/S0378-1119(01)00651-5 .
3. Lee CW, Rivera R, Gardell S, Dubin AE, Chun J . GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5 . The Journal of Biological Chemistry . 281 . 33 . 23589–23597 . August 2006 . 16774927 . 10.1074/jbc.M603670200 . free .
4. Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B . Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes . The Journal of Pharmacology and Experimental Therapeutics . 318 . 2 . 619–628 . August 2006 . 16651401 . 10.1124/jpet.105.098848 . 5989815 .
5. Web site: Entrez Gene: GPR92 G protein-coupled receptor 92.
6. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J . LPA receptors: subtypes and biological actions . Annual Review of Pharmacology and Toxicology . 50 . 1 . 157–186 . January 2010 . 20055701 . 10.1146/annurev.pharmtox.010909.105753 .