| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Luis Antonio de Castro y Castillo | |
| Bishop of La Paz | |
| Church: | Catholic Church |
| Diocese: | Diocese of La Paz |
| Term: | 1647–1653 |
| Predecessor: | Francisco de la Serna |
| Successor: | Martín Velasco y Molina |
| Birth Place: | Alcala la Real |
| Death Date: | 7 October 1653 |
| Death Place: | La Paz, Bolivia |
Luis Antonio de Castro y Castillo (died 1653) was a Roman Catholic prelate who served as Bishop of La Paz (1647–1653).[1]
Luis Antonio de Castro y Castillo was born in Alcala la Real.[2] On 13 September 1647, he was selected as Bishop of La Paz and confirmed by Pope Innocent X on 13 January 1648.On 26 April 1648, he was consecrated bishop by Juan de Arguinao y Gutiérrez, Bishop of Santa Cruz de la Sierra. He served as Bishop of La Paz until his death on 7 October 1653.