| Luís Marques Guedes | |
| Office: | Minister of Regional Development |
| Term Start: | 30 October 2015 |
| Term End: | 26 November 2015 |
| Primeminister: | Pedro Passos Coelho |
| Predecessor: | Miguel Poiares Maduro |
| Successor: | Ana Abrunhosa |
| Office1: | Minister of the Presidency |
| Term Start1: | 13 April 2013 |
| Term End1: | 26 November 2015 |
| Primeminister1: | Pedro Passos Coelho |
| Predecessor1: | Pedro Silva Pereira |
| Successor1: | Maria Manuel Leitão Marques |
| Office2: | Minister of Parliamentary Affairs |
| Term Start2: | 13 April 2013 |
| Term End2: | 30 October 2015 |
| Primeminister2: | Pedro Passos Coelho |
| Predecessor2: | Miguel Relvas |
| Successor2: | Carlos Costa Neves |
| Office3: | Secretary of State for the Presidency of the Council of Ministers |
| Term Start3: | 21 June 2011 |
| Term End3: | 13 April 2013 |
| Primeminister3: | Pedro Passos Coelho |
| Predecessor3: | João Tiago Silveira |
| Successor3: | Tiago Antunes |
| Office4: | Secretary-General of the Social Democratic Party |
| Term Start4: | 20 June 2008 |
| Term End4: | 11 October 2010 |
| President4: | Manuela Ferreira Leite Pedro Passos Coelho |
| Predecessor4: | José Ribau Esteves |
| Successor4: | Miguel Relvas |
| Office5: | Secretary of State Assistant to the Prime Minister |
| Term Start5: | 7 December 1993 |
| Term End5: | 28 October 1995 |
| Primeminister5: | Aníbal Cavaco Silva |
| Predecessor5: | António Campos |
| Successor5: | Joaquim Pina Moura |
| Birth Date: | 25 August 1957 |
| Birth Place: | Lisbon, Portugal |
| Party: | Social Democratic Party |
| Spouse: | Ana Carlota de Andrade |
| Children: | 2 |
| Alma Mater: | University of Lisbon |
| Term Start6: | 31 October 1995 |
| Term End6: | 28 March 2022 |
| Constituency6: | Porto (1995–1999) Santarém (1999–2002) Lisbon (2002–2022) |
Luís Maria de Barros Serra Marques Guedes (born 25 August 1957) is a Portuguese lawyer and politician. He was Secretary of State for the Presidency of the Council of Ministers of the government of Pedro Passos Coelho, Secretary of State to the Prime Minister of Portugal, and the Government XII Undersecretary of State Assistant to the Prime Minister. He held the position of Chairman of the Parliamentary Group of the Social Democratic Party, of which he has been a member since 1995. When he ceased his activities as Minister of the Presidency, in late 2015, he became President of the Parliamentary Commission on Ethics, a section of the First Commission on Fundamental Rights.
He was deputy mayor of Cascais, and was responsible for the legal departments, municipal police, and civil protection. He was also a member of the Municipal Assembly of Cascais and chairman of the Youth Institute.
He is a younger brother of Armando Marques Guedes, political scientist, anthropologist and former diplomat.