| Louis Setshwane | |
| Fullname: | Louis Setshwane |
| Birth Place: | Botswana |
| Position: | Midfielder |
| Years1: | 1998–1999 |
| Clubs1: | Botswana Defence Force XI |
| Nationalyears1: | 1999 |
| Nationalteam1: | Botswana |
| Nationalcaps1: | 1 |
| Nationalgoals1: | 0 |
Louis Setshwane is a Motswana former professional footballer who played primarily as a midfielder. He won one cap for the Botswana national team in 1999.