| Little Buffalo River | |
| Source1 Location: | northern Lawrence County, near Laurel Hill. |
| Source1 Coordinates: | 35.2973°N -87.4739°W |
| Mouth Coordinates: | 35.4504°N -87.5314°W |
| Progression: | Lawrence County Lewis County |
| Length: | 18.1miles |
| Source1 Elevation: | 980feet |
| Mouth Elevation: | 673feet |
| River System: | Tennessee River Basin |
The Little Buffalo River is an 18.1adj=midNaNadj=mid[1] tributary of the Buffalo River in the U.S. state of Tennessee. Via the Buffalo, Duck, Tennessee, and Ohio rivers, it reaches the Mississippi River.
It rises a short distance south of Deerfield in northern Lawrence County, Tennessee, near Laurel Hill. Its major tributaries are Jacks Branch, which follows the Natchez Trace Parkway for approximately a mile and is the site of picnic areas, trails, and rest rooms, and Chief Creek, which is also crossed by the Natchez Trace Parkway, as is the Little Buffalo itself. The Little Buffalo empties into the Buffalo River near State Route 99 in Lewis County.
The Hydrologic Unit Code (HUC-12) for the Little Buffalo is 060400040106. The Little Buffalo is a part of the Upper Buffalo River watershed which is HUC-10 0604000401.