This is a list of the Spanish PROMUSICAE Top 20 Singles number-ones of 2001.[1]
| Issue Date | Song | Artist | |
|---|---|---|---|
| 1 January | No cambié | Tamara | |
| 8 January | Jennifer Lopez | ||
| 15 January | |||
| 22 January | |||
| 29 January | La otra orilla (Un pueblo) | Reincidentes | |
| 5 February | |||
| 12 February | |||
| 19 February | |||
| 26 February | Carnavalito | King África | |
| 5 March | |||
| 12 March | |||
| 19 March | |||
| 26 March | |||
| 2 April | Gypsy Teens | ||
| 9 April | |||
| 16 April | |||
| 23 April | Depeche Mode | ||
| 30 April | |||
| 7 May | |||
| 14 May | Manu Chao | ||
| 21 May | |||
| 28 May | |||
| 4 June | |||
| 11 June | Prohibida | Raúl | |
| 18 June | |||
| 25 June | |||
| 2 July | |||
| 9 July | |||
| 16 July | Melody | ||
| 23 July | Christina Aguilera, Lil' Kim, Mýa & Pink featuring Missy Elliott | ||
| 30 July | |||
| 6 August | Björk | ||
| 13 August | Jamiroquai | ||
| 20 August | |||
| 27 August | |||
| 3 September | |||
| 10 September | The Chemical Brothers | ||
| 17 September | |||
| 24 September | |||
| 1 October | |||
| 8 October | Michael Jackson | ||
| 15 October | Enrique Iglesias | ||
| 22 October | Partiendo la pana | Estopa | |
| 29 October | Suerte | Shakira | |
| 5 November | Academia Operacion Triunfo Gala 1 | ||
| 12 November | Academia Operacion Triunfo Gala 2 | ||
| 19 November | Kylie Minogue | ||
| 26 November | |||
| 3 December | |||
| 10 December | Blind Guardian | ||
| 17 December | |||
| 24 December | Can't Get You Out of My Head | Kylie Minogue | |
| 31 December | Abre tu sonrisa | Sugarless |